Evidence map›Paper›PMID 42106025›Full record

ArticleJournal of immunology research2026

Sensitization of Common Allergens and Cosensitization Patterns Among Children in Guangzhou, China.

Xiaoyin Zeng, Haiyan Wang, Xiaoying Lin, Miaona Shen, Hailei Chen, Yan Huang, Qianwen Huang, Xiang Liu, Weiping Tan, Yong Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xiaoyin ZengHematologic Laboratory of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China, sysu.edu.cn.
Haiyan WangGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China, sysu.edu.cn.
Xiaoying LinHematologic Laboratory of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China, sysu.edu.cn.
Miaona ShenHematologic Laboratory of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China, sysu.edu.cn.
Hailei ChenHematologic Laboratory of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China, sysu.edu.cn.
Yan HuangHematologic Laboratory of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China, sysu.edu.cn.
Qianwen HuangHematologic Laboratory of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China, sysu.edu.cn.
Xiang LiuGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China, sysu.edu.cn.ORCID https://orcid.org/0000-0002-9367-6549
Weiping TanGuangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China, sysu.edu.cn.ORCID https://orcid.org/0000-0002-7644-0358
Yong LiuHematologic Laboratory of Pediatrics, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, 510120, China, sysu.edu.cn.ORCID https://orcid.org/0000-0003-3225-0357

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPediatric allergic diseases vary by region. Subtropical sensitization profiles and their clinical implications remain poorly defined.

methodIn this retrospective study, specific immunoglobulin E (sIgE) levels to eight common allergens were obtained from children assessed for allergy-associated symptoms in our department between November 1, 2017, and April 29, 2020.

resultOf the 1755 patients, Dermatophagoides pteronyssinus (Der p) (46.5%) and Dermatophagoides farinae (Der f; 45.7%) showed high rates of sensitization. More than 80% of shrimp-sensitized children exhibited cross-reactivity to Der p, Der f, and cockroach. After adjusting for potential confounding variables, inhalant sensitization (OR = 2.131; 95% confidence interval [CI]: 1.506-3.015; p  < 0.001) and polysensitization (OR = 1.480; 95% CI: 1.023-2.141; p = 0.038) were both associated with an increased risk of allergic airway disease.

conclusionOur study identified the "mite-shrimp" sensitization cluster in subtropical children and establishes inhalant sensitization and polysensitization as the key risk factor in allergic respiratory diseases. These findings support the development of region-specific and component-resolved diagnostic strategies for pediatric allergy prevention.

Indexed as

AllergensHypersensitivityAdolescentAnimalsAntigens, DermatophagoidesChildChild, PreschoolChinaCross ReactionsDermatophagoides pteronyssinusFemaleHumansImmunizationImmunoglobulin EInfantMaleAllergensAntigens, DermatophagoidesImmunoglobulin Eallergic respiratory diseasesfood allergeninhalant allergenlogistic regression analysispolysensitization patterns

Identifiers

PMID42106025
PMCPMC13157309

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.