Evidence map›Paper›PMID 42106024›Full record

ArticleJournal of immunology research2026

Clinical Significance of B7-H4 in Peripheral Blood of Patients With Myasthenia Gravis.

Xiaoling Zhou, Yunfei Zhu, Tiantian Gui, Yanzheng Gu, Haifeng Lu, Wentong Ju, Jingluan Tian, Qun Xue

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiaoling ZhouDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, Jiangsu, China, sdfyy.cn.ORCID https://orcid.org/0000-0002-6922-1245
Yunfei ZhuDepartment of Neurology, The Fourth Affiliated Hospital of Soochow University, Suzhou, 215123, Jiangsu, China.ORCID https://orcid.org/0009-0002-5479-1680
Tiantian GuiDepartment of Neurology, The People's Hospital of Guangxi Zhuang Autonomous Region, Guangxi Academy of Medical Sciences, Nanning, 530021, Guangxi, China, gxhospital.com.
Yanzheng GuInstitute of Clinical Immunology, Jiangsu Key Laboratory of Clinical Immunology, The First Affiliated Hospital of Soochow University, Suzhou, 215006, Jiangsu, China, sdfyy.cn.
Haifeng LuDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, Jiangsu, China, sdfyy.cn.
Wentong JuDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, Jiangsu, China, sdfyy.cn.
Jingluan TianDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, Jiangsu, China, sdfyy.cn.ORCID https://orcid.org/0000-0001-7243-1633
Qun XueDepartment of Neurology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, Jiangsu, China, sdfyy.cn.ORCID https://orcid.org/0000-0002-7324-7982

Funding

National Natural Science Foundation of China 82371365Soochow University Collaborative Innovation Center Research Project H230028Soochow University Collaborative Innovation Center Research Project H231180Soochow University Collaborative Innovation Center Research Project H240216Soochow University Collaborative Innovation Center Research Project H240669Soochow University Collaborative Innovation Center Research Project H240827The First Affiliated Hospital of Soochow University Clinical Diagnosis and Treatment Technology Innovation Program 0302020301030
6 · The paper itself

Abstract

objectivesThis study aimed to systematically investigate the dynamics changes in membrane-bound B7-H4 (mB7-H4) expression and soluble B7-H4 (sB7-H4) levels in the peripheral blood of patients with acetylcholine receptor antibodies (AchR-Ab)-positive myasthenia gravis (MG) across different disease phases, and to explore their clinical significance.

methodsAchR-Ab-positive MG patients at baseline, relapse, and remission stages, along with age- and sex-matched healthy controls (HCs), were enrolled. Peripheral blood was obtained from all participants. mB7-H4 expression on circulating immune cell subsets was determined by flow cytometry, while plasma sB7-H4 concentration was quantified using enzyme-linked immunosorbent assay (ELISA).

resultsCompared to HC, patients with relapsing MG exhibited significantly increased mB7-H4 expression on CD4

conclusionsDuring MG relapse, inflammatory activation may engage the B7-H4 pathway, characterized by increased mB7-H4 and decreased sB7-H4 levels, which may cooperatively contribute to immune suppression and serve as a compensatory protective mechanism. B7-H4 expression appears to be associated with disease severity. Thymic abnormalities may contribute to the downregulation of sB7-H4, whereas immunosuppressive treatment may not significantly modify its circulating levels. Although increased CD4

Indexed as

Myasthenia GravisV-Set Domain-Containing T-Cell Activation Inhibitor 1AdultAgedAutoantibodiesBiomarkersCD4-Positive T-LymphocytesFemaleHumansMaleMiddle AgedReceptors, CholinergicRecurrenceYoung AdultAutoantibodiesBiomarkersReceptors, CholinergicV-Set Domain-Containing T-Cell Activation Inhibitor 1VTCN1 protein, humanautoreactive T cellimmunoregulationmembrane-bound B7-H4myasthenia gravisperipheral bloodsoluble B7-H4

Identifiers

PMID42106024
PMCPMC13157312

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.