ArticleCurrent biology : CB2026
Inverse expression of Ten3 and Lphn2 across the developing mouse brain suggests a global strategy for circuit assembly.
Article in Current biology : CB, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Ten3-Lphn2-mediated target selection across the extended hippocampal network demonstrates a repeated strategy for circuit assembly.Current biology : CB · 2026Article
- Teneurin-3 and latrophilin-2 are required for somatotopic map development and somatosensory topognosis.Current biology : CB · 2026Article
- Adhesion G-Protein Coupled Receptors in Neurological and Psychiatric Disorders.Journal of psychiatry and brain science · 2025Article
- Teneurin-3 and latrophilin-2 are required for somatotopic map formation and somatosensory topognosis.bioRxiv : the preprint server for biology · 2025Article
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Abstract
Precise wiring of neural circuits requires molecular strategies that ensure accurate target selection across diverse brain regions. Here, we identify inverse expression between a ligand-receptor pair, teneurin-3 (Ten3) and latrophilin-2 (Lphn2), across the developing mouse brain. Ten3 and Lphn2 exhibit inverse expression gradients along a retinotopic axis orthogonal to the ephrinA and EphA gradients, along the tonotopic axis across multiple brainstem auditory nuclei, and along the dorsomedial-ventrolateral axis in striatum and pallidum. Their inverse expression also creates discrete domains of cerebellar Purkinje cells (PCs) and cerebellar nuclei (CN). Using conditional-tag mice, we show that inverse Ten3 and Lphn2 expression patterns predict connectivity, following a "Ten3→Ten3, Lphn2→Lphn2" rule in all above circuits, and that Lphn2 is required in executing this rule in PCs→CN projection. Our findings suggest a global strategy of coordinating gene expression of key wiring molecules with circuit connectivity across the developing brain.
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