Evidence map›Paper›PMID 42105351›Full record

ArticleChemistry & biodiversity2026

Cuevaenes F-H, Including Two Rare Chlorinated Cuevaenes From the Marine-Derived Streptomyces malaysiensis HNM0561.

Yan-Ping Huang, Yan-Fang Luo, Zhi-Wei Hong, Shen-Hao Luo, Shuang-Qing Zhou, Xiao-Long Huang, Zhong-Ping Jiang

Abstract read
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Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yan-Ping HuangSchool of Life and Health Sciences, Hainan International One Health Institute, Hainan University, Haikou, China.
Yan-Fang LuoGuangdong Corps Hospital, Chinese People's Armed Police Force, Guangzhou, China.
Zhi-Wei HongSchool of Life and Health Sciences, Hainan International One Health Institute, Hainan University, Haikou, China.
Shen-Hao LuoSchool of Life and Health Sciences, Hainan International One Health Institute, Hainan University, Haikou, China.
Shuang-Qing ZhouCollege of Pharmacy, Guilin Medical University, Guilin, China.
Xiao-Long HuangSchool of Life and Health Sciences, Hainan International One Health Institute, Hainan University, Haikou, China.
Zhong-Ping JiangSchool of Pharmaceutical Sciences, Key Laboratory of Tropical Biological Resources of Ministry of Education, Hainan University, Haikou, China.ORCID https://orcid.org/0009-0008-8372-6670

Funding

Chunhui Program cooperative scientific research project of the Ministry of Education in 2019 RZ2000010713National Natural Science Foundation of China 82460696open foundation of Key Laboratory of Tropical Plant Resource Chemistry of Hainan Province rdzw2025s01
6 · The paper itself

Abstract

Three new cuevaenes, designated cuevaenes F-H (1-3), together with four known analogues (4-7), were isolated from the marine-derived strain Streptomyces malaysiensis HNM0561. Their structures and absolute configurations were elucidated using HR-ESIMS, extensive 1D and 2D NMR spectroscopy, and ECD calculations. Notably, this study establishes the absolute configurations of previously reported cuevaenes (4, 5, and 7) for the first time. Compounds 1 and 2 are distinguished by a rare chlorine substitution at C-17, representing a novel structural motif within the cuevaene family. Additionally, compounds 1-6 were derivatized via esterification with (trimethylsilyl)diazomethane (TMSCHN

Indexed as

StreptomycesAnimalsCell LineDose-Response Relationship, DrugLipopolysaccharidesMiceMicrogliaMolecular StructureNitric OxideStructure-Activity RelationshipLipopolysaccharidesNitric Oxideabsolute configurationanti‐neuroinflammatory activitycuevaenepolyketidesStreptomyces malaysiensis

Identifiers

PMID42105351
PMCPMC13376723

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.