Evidence map›Paper›PMID 42105301›Full record

ArticleJournal of veterinary internal medicine2026

Delta (Δ) 12-lead electrocardiography and vectorcardiography to identify the origin of focally induced atrial and ventricular premature depolarizations in horses.

Ellen Paulussen, Gunther van Loon, Eva Buschmann, Ingrid Vernemmen, Tammo Delhaas, Annelies Decloedt, Glenn Van Steenkiste

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Article in Journal of veterinary internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Ellen PaulussenEquine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.ORCID 0000-0002-4012-2841
Gunther van LoonEquine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.ORCID 0000-0001-5191-5241
Eva BuschmannEquine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.ORCID 0000-0002-2361-6225
Ingrid VernemmenEquine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.ORCID 0000-0002-8185-1450
Tammo DelhaasDepartment of Biomedical Engineering, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.ORCID 0000-0001-6897-9700
Annelies DecloedtEquine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.ORCID 0000-0001-8129-2006
Glenn Van SteenkisteEquine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.ORCID 0000-0002-0165-5215

Funding

Research Foundation Flanders 1S71521NResearch Foundation Flanders 1SE9122NSpecial Research Fund Ghent University 01B05818
6 · The paper itself

Abstract

backgroundCardiac arrhythmias are common in horses, but their clinical and prognostic relevance remains poorly defined. Despite the importance of localization for diagnosis and treatment, noninvasive methods to identify arrhythmogenic foci are limited. HYPOTHESIS/

objectivesEvaluate the ability of delta (Δ) 3- and 12-lead ECGs and 2-dimensional (2D) and 3-dimensional (3D) vectorcardiography (VCG) to identify the site of origin of focally induced atrial and ventricular premature depolarizations in horses. ANIMALS: Eight healthy horses underwent 2 electrophysiological studies, 1 standing, and 1 under general anesthesia.

methodsPremature atrial and ventricular complexes were induced by intracardiac pacing at 29 anatomical sites. Simultaneous Δ 12-lead ECG and VCG recordings were obtained. Mean vector directions were analyzed, and classification accuracy was assessed at the chamber, regional, and site-specific levels.

resultsDistinct pacing sites produced reproducible and location-specific activation patterns. For differentiating left- from right-sided origins, 3D-VCG had 99% and 82% accuracies for ventricular and atrial origins, respectively. The simplified Δ-based 2D-VCG also showed strong performance on the chamber level, with accuracies of 94% and 78%, respectively. Accuracy was lower for fine-grained intra-chamber localization, especially in the atria. CONCLUSIONS AND CLINICAL IMPORTANCE: Although 3D-VCG offers superior spatial resolution, 2D-VCG provides a good balance between diagnostic accuracy and practical applicability, especially for left- vs right-sided localization. Combined Δ 12-lead ECG and VCG enables accurate, noninvasive chamber-level localization of arrhythmia origins in horses. Standardized application in larger cohorts with naturally occurring arrhythmias may support targeted ablation strategies and improve arrhythmia management and sudden cardiac death risk stratification.

Indexed as

Atrial Premature ComplexesElectrocardiographyHorse DiseasesVectorcardiographyVentricular Premature ComplexesAnimalsFemaleHorsesMalearrhythmiasequinemultiple-lead ECGpacing

Identifiers

PMID42105301
PMCPMC13156935

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.