ArticleClinical and translational science2026
Effects of a High-Fat Meal on the Pharmacokinetics of Olverembatinib in Patients With Chronic Myeloid Leukemia.
Article in Clinical and translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Olverembatinib is approved in China to treat patients with chronic- or accelerated-phase chronic myeloid leukemia (CML-CP or CML-AP) with T315I mutations and CML-CP that is resistant and/or intolerant to first- and second-generation tyrosine kinase inhibitors. The objective of this study was to determine the effects of a high-fat meal on the pharmacokinetics of olverembatinib in patients with CML. Twelve participants were enrolled and received olverembatinib treatment over two periods, with a washout of 7 days between consecutive doses. Pharmacokinetics and safety were assessed in all participants. When olverembatinib was administered with a high-fat meal, the maximum plasma concentration (C
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