Evidence map›Paper›PMID 42105234›Full record

ArticleCell reports2026

Proximity labeling proteomics maps radial glial ciliary proteins across the developing telencephalon.

Xiaoliang Liu, Oscar T Gutierrez, Sabyasachi Baboo, Eva Cai, Gurleen Kaur, Yazan Al-Issa, Jolene K Diedrich, John R Yates, Xuecai Ge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Xiaoliang LiuDepartment of Molecular and Cell Biology, University of California, Merced, Merced, CA 95340, USA. Electronic address: xiaoliang.liu01@hotmail.com.
Oscar T GutierrezDepartment of Molecular and Cell Biology, University of California, Merced, Merced, CA 95340, USA.
Sabyasachi BabooDepartment of Integrative Structural & Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Eva CaiDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA 92521, USA.
Gurleen KaurDepartment of Molecular and Cell Biology, University of California, Merced, Merced, CA 95340, USA.
Yazan Al-IssaDepartment of Molecular and Cell Biology, University of California, Merced, Merced, CA 95340, USA.
Jolene K DiedrichDepartment of Integrative Structural & Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
John R YatesDepartment of Integrative Structural & Computational Biology, The Scripps Research Institute, La Jolla, CA, USA.
Xuecai GeDepartment of Molecular and Cell Biology, University of California, Merced, Merced, CA 95340, USA; Division of Biomedical Sciences, School of Medicine, University of California, Riverside, Riverside, CA 92521, USA. Electronic address: xuecaig@ucr.edu.

Funding

Regulation of the Hedgehog Pathway by new cilium proteins in Development and DiseaseR01GM143276 · NIGMS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI GE, XUECAI · 2022 to 2025
$1.5M
Target PDE4D to inhibit the Hedgehog pathwayR15CA235749 · NCI · UNIVERSITY OF CALIFORNIA, MERCED · PI GE, XUECAI · 2019 to 2022
$795k
Mechanistic study of Hedgehog signaling in the ciliumR21CA274595 · NCI · UNIVERSITY OF CALIFORNIA, MERCED · PI GE, XUECAI · 2022 to 2022
$385k
NCI NIH HHS R15 CA235749NCI NIH HHS R21 CA274595NIGMS NIH HHS R01 GM143276
6 · The paper itself

Abstract

Primary cilia in radial glia act as signaling hubs essential for brain development, yet their molecular roles remain poorly understood. Here, using proximity-labeling-mediated in vivo proteomics, we systematically mapped ciliary proteins in the developing telencephalon. Our dataset reveals region-specific ciliary composition across the dorsal and ventral telencephalon. We identified and validated ribosome proteins and translational machinery components in radial glial cilia. Further, we uncovered ciliary roles for neurodevelopmental disorder-associated proteins, including MARCKS, a key regulator of radial glial polarity, and CKAP2L, a protein linked to Filippi syndrome. Functional studies show that MARCKS contributes to ciliogenesis and CKAP2L regulates neurogenesis by modulating Hedgehog signaling. These findings highlight previously unrecognized mechanisms by which primary cilia modulate brain formation. Our in vivo ciliary proteomic dataset provides a unique resource for understanding ciliary functions in brain development and developmental disorders.

Indexed as

CiliaEpendymoglial CellsProteomicsTelencephalonAnimalsHedgehog ProteinsMiceNeurogenesisSignal TransductionHedgehog ProteinsCKAP2Lcortical developmentCP: genomicsCP: neurosciencedevelopmental disorderslocal translationMARCKSprimary ciliumproximity labelingquantitative proteomicsradial gliaTurboID

Identifiers

PMID42105234
PMCPMC13268694

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.