Evidence map›Paper›PMID 42105152›Full record

ArticleMagma (New York, N.Y.)2026

The MRI two-perfusion IVIM model improves understanding of SARS-CoV-2 virus impact on placental tissue.

Alessandra Maiuro, Claudia Cutonilli, Giada Ercolani, Marco Gennarini, Daniele Di Mascio, Maria Grazia Porpora, Carlo Catalano, Giuseppe Rizzo, Antonella Giancotti, Lucia Manganaro and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Alessandra MaiuroDepartment of Physics, Sapienza University of Rome, Rome, Italy.
Claudia CutonilliDepartment of Radiological,, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
Giada ErcolaniDepartment of Radiological,, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
Marco GennariniDepartment of Radiological,, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
Daniele Di MascioDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Maria Grazia PorporaDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Carlo CatalanoDepartment of Radiological,, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
Giuseppe RizzoDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Antonella GiancottiDepartment of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy.
Lucia ManganaroDepartment of Radiological,, Oncological and Pathological Sciences, Umberto I Hospital, Sapienza University of Rome, Rome, Italy.
Silvia CapuaniInstitute of Complex Systems (ISC), National Council of Research (CNR), Rome, Italy. silvia.capuani@roma1.infn.it.ORCID http://orcid.org/0000-0002-7863-1801

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDiffusion-weighted imaging (DWI) has been adopted to study placentas of women infected by SARS-CoV-2, highlighting the microstructural deterioration of the tissues using the Intravoxel Incoherent Motion model (IVIM). However, unlike the results obtained on placental histology, no perfusion impairment was observed. We used the Two-perfusion IVIM model to investigate the placenta's perfusion compartments.

methodsDWIs of n = 12 patients affected by SARS-CoV-2 and n = 20 gestational age-matched pre-pandemic healthy subjects were acquired at 1.5 T scanner with 10 b values. The maternal and fetal placentae were investigated. Differences in the two groups were evaluated using Welch's t test.

resultsThe placental fetal side showed higher values of D and lower values of f2 (relative to the trophoblast compartment) in SARS-CoV-2 patients. D2* was higher on the maternal side of SARS-CoV-2 patients. DISCUSSION: Higher values of D reflect damage to the tissue, while the lower f2 parameter suggested an impairment of the exchange between mother and fetus. The higher values of D2* in the maternal side of SARS-CoV-2 placentas may be due to a decreased capillaries' size caused by the infiltration of lymphocytes in the decidua basalis. These results further confirm the potential of the two-perfusion IVIM model in detecting placental dysfunction.

Indexed as

COVID-19IVIMPlacentaSARS-Cov-2Two-perfusion IVIM

Identifiers

PMID42105152

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.