Evidence map›Paper›PMID 42105143›Full record

ArticleMolecular diversity2026

Molecularly diverse lonazolac-inspired pyrazole-cyanopyridin-2-one conjugates: design, synthesis, in vitro, in vivo and in silico studies as multi-target anti-inflammatory agents.

Marwa A Aziz, Azizah M Malebari, Tarek S Ibrahim, Mohamed F Radwan, Deiaa E Elsayed Abouzed, Rasha M Allam, Majed Alharbi, Ahdab N Khayyat, Gamal El-Din A Abuo-Rahma, Mamdouh F A Mohamed

Abstract read
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Article in Molecular diversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marwa A AzizFaculty of Pharmacy, Department of Medicinal Chemistry, Minia University, Minia, 61519, Egypt.
Azizah M MalebariFaculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Tarek S IbrahimFaculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Mohamed F RadwanFaculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Deiaa E Elsayed AbouzedFaculty of Pharmacy, Department of Pharmacology & Toxicology, Sohag University, Sohag, 82524, Egypt.
Rasha M AllamPharmacology Department, Medical Research Institute, National Research Centre, Dokki, 12622, Cairo, Egypt.
Majed AlharbiFaculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Ahdab N KhayyatFaculty of Pharmacy, Department of Pharmaceutical Chemistry, King Abdulaziz University, 21589, Jeddah, Saudi Arabia.
Gamal El-Din A Abuo-RahmaFaculty of Pharmacy, Department of Medicinal Chemistry, Minia University, Minia, 61519, Egypt. gamal.aborahma@mu.edu.eg.
Mamdouh F A MohamedFaculty of Pharmacy, Department of Pharmaceutical Chemistry, Sohag University, Sohag, 82524, Egypt. mamdouh.fawzi@pharm.sohag.edu.eg.

Funding

The Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Saudi Arabia RG-32-166-43
6 · The paper itself

Abstract

New pyrazole/3-cyanopyridin-2-one conjugates 4a-f and 5a-h were designed and synthesized; their anti-inflammatory activities were evaluated in vitro and in vivo. In the LPS-induced RAW 264.7 cell line, nitric oxide (NO) inhibitory activity revealed that 4b, 4e, and 5c were the most powerful NO inhibitors, with % inhibition of 64.97, 71.45 and 73.61, respectively, compared with indomethacin (60.97). Hybrids 4f (IC

Indexed as

5-LOX and NOS inhibitorsAnti-InflammatoryHealthcareIn-Silico StudyPyrazole/Cyanopyridine conjugates, Selective COX-2 inhibitors

Identifiers

PMID42105143

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.