Observational studyArchives of women's mental health2026
Women with first-episode psychosis: diagnostic stability and clinical trajectories.
Observational study in Archives of women's mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
purposeThe aim of this study was to assess the influence of sex on diagnostic stability in first-episode psychosis during the first year of follow-up.
methodsThis was a prospective, observational study of 256 patients with FEP, of whom 188 (73.4%) completed the 1-year follow-up. Patients were consecutively recruited at a specialized early intervention program. Comprehensive psychiatric evaluations and the Structured Clinical Interview for DSM-IV-TR Axis I disorders were performed at baseline and follow-up. Diagnoses were grouped into affective and non-affective psychoses. Univariate and multivariate logistic regression analyses were conducted to identify predictors of diagnostic shift, with a particular focus on sex.
resultsAt one-year follow-up, 48.9% of patients experienced some form of diagnostic change. Specifically, 14.4% shifted from non-affective to affective psychosis. Female sex was the only independent predictor of diagnostic shift (OR = 0.30; 95% CI = 0.10-0.87; p = 0.027). No other clinical or demographic variables were significantly associated with diagnostic change.
conclusionFemale FEP patients were significantly more likely to experience a diagnostic shift toward affective psychosis during the first year of follow-up. These findings highlight the importance of considering sex differences in clinical presentation at illness onset to improve diagnostic accuracy, optimize treatment strategies, and enhance long-term outcomes.
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