ArticleJournal of bioenergetics and biomembranes2026
Dynamic changes in mitochondrial function in brain cortex synaptosomes during aging.
Article in Journal of bioenergetics and biomembranes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Alterations in mitochondrial function and in reactive oxygen species generation have been associated with physiological aging. In this study, mice aged 3, 10, 20, and 24 months were utilized to investigate the changes in mitochondrial function and reactive oxygen species (ROS) at synapses. Mitochondrial membrane potential was 21% decreased in 20 months-old animals, while it increased (24%) at advanced age (24 months), compared with young mice. Coupling efficiency and ATP synthesis decreased in synaptosomes from 24-months old mice. Regarding mitochondrial respiratory complex activity, reductions in complex II-III and IV activity were observed (42% and 47%, respectively) at 10 months of age. A significant increase in complex I-III activity (48%) was found at 20 months, with no changes in complexes II-III or complex IV enzymatic activities. Likewise, complex II-III activity showed an increase (100%) at 24 months, while complex I-III significantly decreased (37%). An age-related increase in superoxide generation was observed, consistent with impaired respiratory chain function. Interestingly, H
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