Evidence map›Paper›PMID 42105042›Full record

ArticleMolecular neurobiology2026

Glycogen Synthase Kinase-3β Mediates Suppression of Neurite Outgrowth Through Sonic Hedgehog Signalling in Palmitic Acid-Exposed Neuro2A Cells.

Pooja Singh, Shonak Vrujlal Ambaliya, Gajjar Shivam Kumar, Shreyash Santosh Yadav, Ashok Kumar Datusalia

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Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Pooja SinghLaboratory of Molecular NeuroTherapeutics, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) Raebareli, U.P, Lucknow, 226002, India.
Shonak Vrujlal AmbaliyaLaboratory of Molecular NeuroTherapeutics, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) Raebareli, U.P, Lucknow, 226002, India.
Gajjar Shivam KumarLaboratory of Molecular NeuroTherapeutics, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) Raebareli, U.P, Lucknow, 226002, India.
Shreyash Santosh YadavLaboratory of Molecular NeuroTherapeutics, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) Raebareli, U.P, Lucknow, 226002, India.
Ashok Kumar DatusaliaLaboratory of Molecular NeuroTherapeutics, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research (NIPER) Raebareli, U.P, Lucknow, 226002, India. ashok.datusalia@niperraebareli.edu.in.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Metabolic stress induced by saturated fatty acids such as palmitic acid (PA) disrupts key signalling pathways involved in neuronal survival, differentiation, and plasticity. The Sonic Hedgehog (Shh) pathway, essential for neurogenesis and tissue regeneration, is particularly vulnerable to PA-mediated suppression. In this study, we investigated the therapeutic potential of purmorphamine, a smoothened (SMO) agonist, and lithium chloride (LiCl), a GSK3β inhibitor, in restoring metabolic stress-induced insulin resistance and Shh signalling in Neuro2A cells. For the induction of insulin resistance or metabolic stress model, N2a cells were treated with PA (200 μM) for 24 h and validated by stimulation with insulin (100 nM) for various time periods 0, 5, 15, 30, 60, and 120 min. A blunted response was observed on pAKT

Indexed as

Glycogen Synthase Kinase 3 betaHedgehog ProteinsNeuronal OutgrowthPalmitic AcidSignal TransductionAnimalsCell Line, TumorLithium ChlorideMiceMorpholinesPurinesGlycogen Synthase Kinase 3 betaHedgehog ProteinsLithium ChlorideMorpholinesPalmitic AcidPurinespurmorphamineGSK3βInsulin resistanceLithium chlorideNeurite outgrowthPalmitic acidSonic hedgehog signaling

Identifiers

PMID42105042

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.