ReviewChemistry (Weinheim an der Bergstrasse, Germany)2026
Programmable DNA Logic Systems for Applications in Biomedicine.
Review in Chemistry (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
DNA has emerged as a versatile molecular engineering material owing to its predictable base-pairing rules, structural programmability, and excellent biocompatibility. Programmable DNA logic systems capable of integrating diverse biological signals and execute predefined logical operations, bridging molecular computing with biomedical applications. In this review, we summarize recent advances in programmable DNA reaction and logic systems for biomedical applications. We first introduce DNA logic gates responsive to diverse biomolecular and physiological inputs, followed by cascaded DNA reaction circuits and molecular classifiers for amplified signal processing and precision diagnosis. We then discuss DNA nanostructures and intelligent nanomachines that integrate sensing, computation and actuation for therapeutic regulation. Finally, we outline current challenges and future opportunities toward the development of DNA-based intelligent biomedical systems.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.