Evidence map›Paper›PMID 42104901›Full record

ArticleJournal of neuropsychology2026

Preservation of positive emotion recognition in patients with multiple sclerosis: Artefact related to methodological issues or real feature of the disorder?

Laurent Zikos, Antonio Pinti, Henrique Sequeira, Cécile Donze, Arnaud Kwiatkowski, Béatrice Degraeve, Bruno Lenne

Abstract read
In one paragraph

Article in Journal of neuropsychology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Laurent ZikosLille Catholic University, Neurethic Lab / FLSH - ETHICS EA7446, Université Catholique de Lille, Lille, France.ORCID https://orcid.org/0009-0008-2984-6989
Antonio PintiLaboratoire Science de l'information-Communication (LSC/DeVisu), Université Polytechnique Hauts-de-France, Valenciennes, France.
Henrique SequeiraCNRS UMR 9193 - SCALab - Sciences Cognitives et Sciences Affectives, Department of Biology, Faculty of Sciences and Technologies, University of Lille, Lille, France.ORCID https://orcid.org/0000-0003-0619-9199
Cécile DonzeLille Catholic University, Neurethic Lab / FLSH - ETHICS EA7446, Université Catholique de Lille, Lille, France.ORCID https://orcid.org/0000-0001-7884-5845
Arnaud KwiatkowskiLille Catholic University, Neurethic Lab / FLSH - ETHICS EA7446, Université Catholique de Lille, Lille, France.ORCID https://orcid.org/0000-0001-9982-0137
Béatrice DegraeveLille Catholic University, Neurethic Lab / FLSH - ETHICS EA7446, Université Catholique de Lille, Lille, France.ORCID https://orcid.org/0000-0001-5805-0981
Bruno LenneLille Catholic University, Neurethic Lab / FLSH - ETHICS EA7446, Université Catholique de Lille, Lille, France.ORCID https://orcid.org/0000-0002-2150-705X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prior studies in multiple sclerosis (MS) suggest preserved recognition of positive emotions despite deficits for negative ones, but this dissociation may reflect methodological limitations (valence-asymmetry: positive-valence being limited to happiness/joy in basic-emotion sets). This study tested whether emotion-recognition deficits in MS are valence-specific or more generalized using dynamic stimuli and reduced valence-asymmetry, assessed across two sensory modalities. Exploratory analyses also examined cognitive status and correlations with cognitive/affective measures. Fifty relapsing-remitting persons with MS (pwMS) and 50 matched controls completed an emotion-recognition task involving dynamic audio and video stimuli. The task assessed recognition of all six basic emotions and 14 complex emotions. Cognitive and affective measures were collected; exploratory analyses examined cognitive status and associations with these variables. PwMS showed significantly lower recognition accuracy across multiple emotions compared to controls. In the video condition, group differences were stronger for negative emotions (OR = .62, p = .001), whereas no significant group difference was observed for positive emotions. Only a single significant deficit (anger: OR = .52, p = .027) was found in the audio condition. Video subgroup analyses indicated reduced recognition in cognitively impaired pwMS for selected items, whereas pwMS without cognitive impairment did not differ significantly from controls. Findings support a predominant vulnerability for negative emotion-recognition in MS. In the absence of a significant group-level difference, the frequently reported preservation of positive emotion-recognition cannot be attributed to methodological artefacts alone. More broadly, individual patient characteristics, including cognitive functioning, may contribute to heterogeneity in emotion-recognition performance in MS.

Indexed as

EmotionsMultiple SclerosisRecognition, PsychologyAcoustic StimulationAdultCognition DisordersFemaleHumansMaleMiddle AgedNeuropsychological TestsPhotic Stimulationemotional valenceemotion–recognitionfacial expressionsmodalitymultiple sclerosis

Identifiers

PMID42104901
PMCPMC13552246

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.