Evidence map›Paper›PMID 42104850›Full record

ArticleGenetics in medicine : official journal of the American College of Medical Genetics2026

An integrated cardiometabolic genetic testing program in a predominantly Hispanic population within a community setting.

Bo Yuan, Layla A Abushamat, Stacey Pereira, Surya Narayan Mulukutla, Grace E Tietz, Eric Venner, Sara E Kalla, Breanna Lee, Donna Muzny, Ginger Metcalf and 27 more

Abstract read
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In one paragraph

Article in Genetics in medicine : official journal of the American College of Medical Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Bo YuanHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Baylor Genetics, Houston, TX. Electronic address: bo.yuan@bcm.edu.
Layla A AbushamatSection of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX; Section of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX. Electronic address: layla.abushamat@bcm.edu.
Stacey PereiraCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, TX.
Surya Narayan MulukutlaDiabetes and Endocrinology Institute, DHR Health, Edinburg, TX.
Grace E TietzDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Eric VennerHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Sara E KallaHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Breanna LeeHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Donna MuznyHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Ginger MetcalfHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Mullai MuruganHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Sarah H ElseaHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Baylor Genetics, Houston, TX.
Senkottuvelan KadirvelHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Lele LiHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Joshi StephenHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Shengfeng XuHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Victoria YiHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Monica SulitHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Christie L KovarHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Kimberly WalkerHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Marie-Claude GingrasHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Jianhong HuHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Fei YanHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Taeko GerberHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
Viktoriya KorchinaHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX.
C Michael FordisDivision of Continuing Professional Development, CCIT, Baylor College of Medicine, Houston, TX.
Ruchi GabaSection of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX.
Mahesh ChanglaniDHR Health Heart Institute, McAllen and Edinburg, TX.
Herschl SilbermanDHR Health Heart Institute, McAllen and Edinburg, TX.
Hadley Stevens SmithPrecision Medicine Translational Research (PROMoTeR) Center, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.
Christine M EngDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX; Baylor Genetics, Houston, TX.
Jennifer E PoseyDepartment of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Clarisa MedinaDHR Health Institute for Research and Development, Edinburg, TX.
Lisa R TreviñoDHR Health Institute for Research and Development, Edinburg, TX.
Christie M BallantyneSection of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX; Section of Cardiology, Baylor College of Medicine, Houston, TX.
Richard A GibbsHuman Genome Sequencing Center, Baylor College of Medicine, Houston, TX; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX.
Ashok BalasubramanyamSection of Diabetes, Endocrinology and Metabolism, Baylor College of Medicine, Houston, TX.

Funding

Mechanisms and consequences of erythritol and erythronate excess in cardiometabolic diseaseK23DK140641 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI Layla A Abushamat · 2024 to 2026
$583k
NIDDK NIH HHS K23 DK140641
6 · The paper itself

Abstract

purposeThis study aimed to apply cardiometabolic genetic testing in a community setting with a predominantly Hispanic population and assess feasibility and perspectives toward genetic testing.

methodsA genome-sequencing-based genetic panel for cardiometabolic disorders (177 genes related to monogenic conditions, 2 LPA risk alleles, 2 pharmacogenomic loci, and ancestry-adjusted polygenic risk scores for type 2 diabetes and coronary artery disease) was deployed in community cardiology and endocrinology clinics in South Texas. A survey on perceptions toward genetic testing was administered after return of results.

resultsTesting was completed for 776 patients (18-92 years old, 92% Hispanic). 26 patients (3.4%) were identified with a pathogenic or likely pathogenic variant in a monogenic disease gene, including 17 diagnostic and 9 secondary findings. Additionally, 291 (37.5%), 181 (23.3%), and 298 (38.4%) patients were identified with at least 1 LPA risk allele, pharmacogenomic finding, or elevated polygenic risk scores, respectively. Patients perceived the testing to be beneficial with few concerns.

conclusionThis study expanded cardiometabolic genetic testing to a predominantly Hispanic population in a community setting, providing actionable guidance for disease diagnosis, intervention, and preventive care with a favorable patient perception.

Indexed as

Cardiovascular DiseasesGenetic TestingHispanic or LatinoAdolescentAdultAgedAged, 80 and overAllelesCoronary Artery DiseaseDiabetes Mellitus, Type 2FemaleGenetic Predisposition to DiseaseGenetic Risk ScoreHumansMaleMiddle AgedCardiometabolic disordersCommunity-based genetic testingHispanic population

Identifiers

PMID42104850
PMCPMC13430617

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.