Evidence map›Paper›PMID 42104804›Full record

Trial reportSchizophrenia bulletin2026

Tracking Symptom Change Across Therapy Sessions in Virtual Reality Cognitive Behavioral Therapy Versus Cognitive Behavioral Therapy for Paranoid Ideation: A Secondary Analysis of a Randomized Controlled Trial.

Maureen Berkhof, Elisabeth Christine Dorothée Van Der Stouwe, Wim Veling, Chris Neeltje Wil Geraets

Abstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in Schizophrenia bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maureen BerkhofDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Elisabeth Christine Dorothée Van Der StouweDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Wim VelingDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.
Chris Neeltje Wil GeraetsDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, 9700 RB Groningen, The Netherlands.ORCID 0000-0002-6401-2073

Funding

Dutch Brain Foundation HA2017.01.04
6 · The paper itself

Abstract

STUDY

designIn this secondary analysis of a randomized controlled trial, individuals aged 18-65 with a psychotic disorder and paranoid ideation were recruited. Ninety-eight participants were randomized to maximally 16 sessions of VR-CBTp (n = 48) or CBTp (n = 50). Self-rated symptom severity, functional impairment, and clinician-rated illness severity were assessed at each therapy session. Analyses on change scores between the first and final session were performed to assess overall improvement, and multilevel regression models explored in-depth session differences. STUDY

resultsClinician-rated paranoia and avoidance improved more rapidly in VR-CBTp than CBTp, with differences emerging from session 3. Patients reported similar progress in both groups over time on symptoms and functional impairment. A greater proportion of VR-CBTp participants completed treatment early, requiring fewer sessions than the CBTp group.

conclusionsTherapists observed faster symptom recovery in paranoia and avoidance in VR-CBTp while requiring fewer sessions than standard CBTp. These findings suggest that VR-CBTp may be more efficient in duration, while broader effects on access and therapist workload remain to be determined.

Indexed as

Cognitive Behavioral TherapyOutcome Assessment, Health CareParanoid DisordersPsychotic DisordersVirtual Reality Exposure TherapyAdolescentAdultAgedFemaleHumansMaleMiddle AgedYoung Adultcognitive behavioral therapyexposureparanoiapsychosissessionvirtual reality

Identifiers

PMID42104804
PMCPMC13156502

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.