Evidence map›Paper›PMID 42104721›Full record

ArticlePain research & management2026

Migraine Features and Nociceptive Profile Do Not Influence Conditioned Pain Modulation in Women With Episodic and Chronic Migraine.

Ana I de-la-Llave-Rincón, Silvia Ambite-Quesada, Juan C Pacho-Hernández, Angela Tejera-Alonso, Cristina Gómez-Calero, César Fernández-de-Las-Peñas, Beatriz Alvarez-Mariño, Lars Arendt-Nielsen, Margarita Cigarán-Méndez

Abstract read
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In one paragraph

Article in Pain research & management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana I de-la-Llave-RincónDepartment of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Rey Juan Carlos University, Madrid, Spain, urjc.es.ORCID https://orcid.org/0000-0003-3087-3614
Silvia Ambite-QuesadaDepartment of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Rey Juan Carlos University, Madrid, Spain, urjc.es.ORCID https://orcid.org/0000-0001-6755-8189
Juan C Pacho-HernándezDepartment of Research and Psychology on Education, Complutense de Madrid University, Madrid, Spain.ORCID https://orcid.org/0000-0003-3197-453X
Angela Tejera-AlonsoDepartment of Psychology, Rey Juan Carlos University, Madrid, Spain, urjc.es.
Cristina Gómez-CaleroDepartment of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Rey Juan Carlos University, Madrid, Spain, urjc.es.ORCID https://orcid.org/0000-0002-6193-358X
César Fernández-de-Las-PeñasDepartment of Physical Therapy, Occupational Therapy, Physical Medicine and Rehabilitation, Rey Juan Carlos University, Madrid, Spain, urjc.es.ORCID https://orcid.org/0000-0003-3772-9690
Beatriz Alvarez-MariñoDepartment of Neurology, Rey Juan Carlos Hospital, Móstoles, Spain.
Lars Arendt-NielsenDepartment of Health Science and Technology, Center for Neuroplasticity and Pain (CNAP), Faculty of Medicine, Aalborg University, Aalborg, Denmark, aau.dk.ORCID https://orcid.org/0000-0003-0892-1579
Margarita Cigarán-MéndezDepartment of Psychology, Rey Juan Carlos University, Madrid, Spain, urjc.es.ORCID https://orcid.org/0000-0002-5105-3722

Funding

Colegio Oficial de Farmacéuticos de MadridIlustre Colegio Profesional de Fisioterapeutas de la Comunidad de Madrid
6 · The paper itself

Abstract

objectiveTo determine the influence of sensitization-associated and neuropathic-like symptoms and clinical features in conditioned pain modulation (CPM) activity in women with episodic or chronic migraine.

methodsA cross-sectional study including 70 women with chronic migraine and 70 with episodic migraine was performed. Clinical migraine features (related disability, pain intensity, frequency, and duration) and pain processing variables (sensitization-associated or neuropathic-like symptoms) were evaluated with self-reported outcomes. Pressure pain thresholds (PPTs) at the temporalis muscle, lateral epicondyle, and tibialis anterior were bilaterally assessed. Heat (HPT) and cold (CPT) pain thresholds at the frontalis (V1 area) muscle were also assessed. Subsequently, CPM was evaluated immediately after a 1-min cold-pressor test paradigm on changes obtained in PPTs, HPT, and CPT.

resultsNo significant group ∗ time interactions after controlling for migraine features, related disability (MIDAS, HIT-6), sensitization-associated (CSI), or neuropathic-like symptoms (S-LANSS) were found for PPTs at the temporalis muscle (Wilk's λ = 0.996, F[1128] = 0.500, p = 0.481, n

conclusionThis study showed similar CPM activation (lack of) in women with episodic and chronic migraine. Thus, clinical features and the presence of sensitization-associated or neuropathic-like symptoms did not modulate CPM activity in women with migraine.

Indexed as

Conditioning, PsychologicalMigraine DisordersPain ThresholdAdultChronic DiseaseCold TemperatureCross-Sectional StudiesFemaleHumansMiddle AgedPain MeasurementYoung Adultconditioned pain modulationdisabilitymigraineneuropathicsensitization

Identifiers

PMID42104721
PMCPMC13156518

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.