Evidence map›Paper›PMID 42104714›Full record

ArticleGenes to cells : devoted to molecular & cellular mechanisms2026

Novel Ligands for the Orphan Receptor GPR151 Modulate Morphine Action.

Hijiri Yoshida, Takashi Suto, Hiroyuki Hirano, Hiroyuki Osada, Kazuto Nunomura, Bangzhong Lin, Shigeru Saito, Shigeki Takeda

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes to cells : devoted to molecular & cellular mechanisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Novel Ligands for the Orphan Receptor GPR151 Modulate Morphine Action.Genes to cells : devoted to molecular & cellular mechanisms · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hijiri YoshidaDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan.
Takashi SutoDepartment of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.ORCID https://orcid.org/0000-0002-5796-4308
Hiroyuki HiranoChemical Resource Development Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, Japan.ORCID https://orcid.org/0000-0002-0761-5548
Hiroyuki OsadaChemical Resource Development Research Unit, RIKEN Center for Sustainable Resource Science, Saitama, Japan.
Kazuto NunomuraDrug Innovation Center, Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Osaka, Japan.ORCID https://orcid.org/0000-0002-6444-3244
Bangzhong LinDrug Innovation Center, Graduate School of Pharmaceutical Sciences, The University of Osaka, Suita, Osaka, Japan.
Shigeru SaitoDepartment of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Shigeki TakedaDivision of Molecular Science, Graduate School of Science and Technology, Gunma University, Kiryu, Gunma, Japan.ORCID https://orcid.org/0000-0001-8979-1133

Funding

Japan Society for the Promotion of Science London JP25K08937
6 · The paper itself

Abstract

GPR151 is an orphan G-protein-coupled receptor expressed on specific neurons. Its expression has been reported to be upregulated in the dorsal root ganglia in mouse nerve injury models, suggesting a role in pain transmission. We used our unique ligand screening system to identify novel agonists and partial agonists for GPR151. The novel ligands, GUM3 and GUM4, have the psoralen ring and exhibited agonist activity (EC

Indexed as

MorphineReceptors, G-Protein-CoupledAnimalsCHO CellsCricetinaeCricetulusHumansHyperalgesiaLigandsMaleRatsRats, Sprague-DawleyStructure-Activity RelationshipLigandsMorphineReceptors, G-Protein-Coupled

Identifiers

PMID42104714
PMCPMC13156533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.