ArticleJournal of cutaneous pathology2026
CADM1 and TIAM1 Expressions in Mycosis Fungoides: Diagnostic Significance and Association With Histopathological Parameters.
Article in Journal of cutaneous pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundMycosis fungoides (MF) is a cutaneous lymphoma that can present various diagnostic challenges. This study aims to evaluate the diagnostic significance of CADM1 and TIAM1 expressions in MF and to assess their association with diagnostic and prognostic histopathological and immunohistochemical parameters.
methodsIn our study, histopathological findings and available CD3, CD4, CD8, CD5, and CD7 immunostaining were evaluated in skin biopsy specimens from 75 MF, 50 inflammatory dermatitis, and 25 control groups. Immunohistochemical CADM1 and TIAM1 staining were applied to all cases.
resultsStatistical analyses demonstrated that CADM1 differentiated MF from inflammatory dermatitis and controls with sensitivity of 93.3% and specificity of 88.0%, and early-stage MF from inflammatory dermatitis and controls with sensitivity of 90% and specificity of 88%. CADM1 was found to be significantly elevated in advanced-stage cases and large cell transformation, independent of age and gender. There was a moderate correlation between CADM1 and TIAM1 in the control group, whereas the correlation was weak in the MF group.
conclusionCADM1 is a sensitive and specific diagnostic marker associated with poor prognosis in MF. It is particularly valuable in early-stage cases, where histopathological distinction from inflammatory dermatoses is most challenging. TIAM1 shows no diagnostic or prognostic utility.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.