Evidence map›Paper›PMID 42104603›Full record

ArticleJournal of hepato-biliary-pancreatic sciences2026

Normothermic Machine Perfusion vs. Static Cold Storage for DBD Liver Transplantation in High-MELD Recipients: A Single-Center Retrospective Study.

Yuzuru Sambommatsu, Daisuke Imai, Kush Savsani, Mallika Datta, Junpei Tarashi, Jacob Hallesy, Samuel Wolfe, Isao Yokota, Seung Duk Lee, David A Bruno

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of hepato-biliary-pancreatic sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

10 authors.

Yuzuru SambommatsuDepartment of Surgery, Division of Transplant Surgery, Hume-Lee Transplant Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0001-7057-1544
Daisuke ImaiDepartment of Surgery, Division of Transplant Surgery, Hume-Lee Transplant Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-4225-8021
Kush SavsaniDepartment of Surgery, Division of Transplant Surgery, Hume-Lee Transplant Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0003-4413-5065
Mallika DattaDepartment of Surgery, Division of Transplant Surgery, Hume-Lee Transplant Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Junpei TarashiDepartment of Surgery, Division of Transplant Surgery, Hume-Lee Transplant Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Jacob HallesyDepartment of Surgery, Division of Transplant Surgery, Hume-Lee Transplant Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Samuel WolfeDepartment of Surgery, Division of Transplant Surgery, Hume-Lee Transplant Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.
Isao YokotaDepartment of Biostatistics, Hokkaido University Graduate School of Medicine, Sapporo, Japan.ORCID https://orcid.org/0000-0001-6254-2225
Seung Duk LeeDepartment of Surgery, Division of Transplant Surgery, Hume-Lee Transplant Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.ORCID https://orcid.org/0000-0002-4382-7871
David A BrunoDepartment of Surgery, Division of Transplant Surgery, Hume-Lee Transplant Center, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeWhile normothermic machine perfusion (NMP) has benefits over static cold storage (SCS), its efficacy in high-acuity recipients with high Model for End-Stage Liver Disease (MELD) scores, particularly using a back-to-base application model, is not well established. We aimed to compare short-term outcomes between NMP and SCS in this cohort.

methodsThis retrospective cohort study analyzed 215 adult recipients with a laboratory MELD score ≥ 25 who underwent isolated liver transplantation from donation after brain death (DBD) donors between July 2022 and June 2024. Patients were divided into SCS (n = 137; median MELD, 35) and NMP (n = 78; median MELD, 36) groups. Outcomes were compared using multivariable regression analyses.

resultsNMP was associated with higher daytime surgery rates (88.5% vs. 23.4%) and lower peak alanine aminotransferase levels (median 298 vs. 653 IU/L). However, no significant differences were found in blood loss, early allograft dysfunction, acute kidney injury, comprehensive complication index, hospital stay, or 90-day graft survival.

conclusionsIn high-MELD recipients of DBD grafts, a predominantly back-to-base NMP approach did not improve major short-term clinical outcomes compared to SCS. Benefits of NMP appear to be highly context-dependent across three axes-graft type, application model (upfront vs. back-to-base), and recipient acuity.

Indexed as

End Stage Liver DiseaseLiver TransplantationOrgan PreservationPerfusionAdultBrain DeathFemaleGraft SurvivalHumansMaleMiddle AgedRetrospective Studiesgraft survivalliver transplantationnormothermic machine perfusionorgan preservationpostoperative complications

Identifiers

PMID42104603
PMCPMC13485208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.