ArticleClinical transplantation2026
Rescue by Hypothermic Oxygenated Machine Perfusion for Unexpected Long Prolongation of Cold Preservation Time in Expanded Criteria Donor Kidneys Can Achieve Favorable 2-Year Outcomes.
Article in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundHypothermic oxygenated machine perfusion (HOPE) is occasionally used to overcome logistical issues and allow longer cold preservation time (CPT); however, reports regarding these situations in older brain-dead donors are lacking.
methodsRetrospective analysis of kidney transplants (KTs) performed between January 1, 2015, to December 31, 2023, from extended criteria donors (ECDs) switched to HOPE after a median time of 17.1 h in static cold storage (SCS) for unexpected logistic reasons and with a median total CPT of 28.6 h (25.3-32.0) (n = 44, HOPE ECDs), compared with a control group of KTs (n = 44, L-ECDs) maintained in SCS alone with a low CPT (median, 10.4 h; range, 7.1-11.1) and matched for age, sex, donor age, donor eGFR, pre-emptive transplant, and cPRA.
resultsNo primary nonfunction was observed, and both death-censored graft survival (DCGS) and renal function progressively improved, remaining satisfactory and superimposable between groups up to two years post-transplant (97.7% of DCGS with mean eGFR 46.5 mL/min/1.73 m
conclusionRescue by HOPE after SCS in ECDs with a very long CPT can achieve midterm outcomes similar to those with a low CPT in SCS alone, paving the way for its safe implementation in clinical practice.
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