Evidence map›Paper›PMID 42104520›Full record

ArticleCritical care (London, England)2026

Epidemiology of the acute respiratory distress syndrome and the prognostic validity of SpO

R M Bennett, K C Housel, T K Jones, T A Miano, G Emre, A Turner, M Esperanza, M Erlich, C Ittner, M G S Shashaty and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

R M BennettDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA. rachel.bennett@pennmedicine.upenn.edu.
K C HouselDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
T K JonesDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
T A MianoCenter for Clinical Epidemiology and Biostatistics, University of Pennsylvania, 432 Guardian Drive, Philadelphia, PA, 10104, USA.
G EmreDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
A TurnerDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
M EsperanzaDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
M ErlichDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
C IttnerDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
M G S ShashatyDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
N J MeyerDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
M R AndersonDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
J D ChristieDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.
J P ReillyDepartment of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA, 19104, USA.

Funding

Cardiology & pulmonary research training grantT32HL007891 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Jason D Christie · 1998 to 2026
$12.0M
TRAINING IN PULMONARY IMMUNOLOGYT32HL007586 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI MEYER, NUALA JENNINGS · 1985 to 2025
$8.8M
Investigating Individual Susceptibility and Host Response in Acute Respiratory Distress SyndromeR35HL161196 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Nuala Jennings Meyer · 2022 to 2026
$4.8M
An ABO Blood Type Defined ARDS Endotype in SepsisR01HL155159 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI REILLY, JOHN PATRICK · 2021 to 2025
$2.7M
NHLBI NIH HHS R01 HL155159NHLBI NIH HHS R35 HL161196NHLBI NIH HHS T32 HL007586NHLBI NIH HHS T32 HL007891
6 · The paper itself

Abstract

The Global consensus definition of acute respiratory distress syndrome (ARDS) broadened the syndrome to include patients on high-flow nasal cannula and hypoxia as defined by the ratio of the saturation of oxygen to fraction of inhaled oxygen (SFR). We sought to compare the incidence and outcomes of ARDS under the 2012 Berlin versus 2023 Global definitions, and to examine the relationship between SFR-derived categories of severity and mortality, in a prospective cohort of critically ill patients with sepsis. Of the 950 included patients, 466 (49%) met criteria for ARDS under the Global definition and 427 (45%) met criteria for ARDS under the Berlin definition during the 6-day follow-up period. Among patients with ARDS, the Global definition allowed for ARDS qualification a median of 3.0 h earlier than the Berlin definition. Mortality was comparable between the Global and Berlin definitions at onset but substantially lower for patients who never went onto meet the Berlin definition. SFR was predictive of 30-day mortality and exhibited moderate correlation with the ratio of partial pressure of oxygen to fraction of inhaled oxygen (PFR). Our work establishes an increased incidence and modestly decreased time to diagnosis of ARDS under the Global definition and supports the prognostic validity of SFR.

Indexed as

OxygenOxygen SaturationRespiratory Distress SyndromeAgedCohort StudiesFemaleHumansIncidenceMalePrognosisProspective StudiesOxygenAcute hypoxic respiratory failureAcute respiratory distress syndrome

Identifiers

PMID42104520
PMCPMC13285079

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.