ArticleNutrition & metabolism2026
Association of pericardial fat volume with risk of incident type 2 diabetes mellitus or major adverse cardiovascular events: Evidence from UK Biobank cohort study.
Article in Nutrition & metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThis study seeks to investigate the relationship between pericardial fat volume and the risk of developing type 2 diabetes mellitus (T2DM) and major adverse cardiovascular events (MACE).
methodsThe analysis included a cohort of 39, 125 participants from the UK Biobank. The associations between the mean estimate pericardial fat area (MEPFA), as measured by cardiac magnetic resonance imaging, and the incidence of T2DM and MACE were evaluated using multivariable Cox proportional hazards regression models and Kaplan-Meier survival curves.
resultsThere were 343 occurrences of new-onset T2DM and 1, 894 occurrences of new-onset MACE over a median follow-up period of 55 months. Compared with patients with MEPFA ≤ 13.80 cm
conclusionsThe findings indicated that elevated MEPFA levels were significantly and independently associated with the onset of T2DM and MACE. Preliminary results suggested that increased levels of pericardial fat might enhance the predictive capability for cardio-metabolic risk.
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