Evidence map›Paper›PMID 42104297›Full record

ArticleBMC neurology2026

The relationship between homocysteine and post-stroke depression in patients with spontaneous intracerebral hemorrhage.

Chao Zhang, Guojuan Chen, Peng Ding, Lei Xiang, Wei Yue

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Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Chao ZhangDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Huanhu Hospital, Tianjin Medical University, 6 Jizhao Rd, Tianjin, 300350, China.
Guojuan ChenDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Huanhu Hospital, Tianjin Medical University, 6 Jizhao Rd, Tianjin, 300350, China.
Peng DingDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Huanhu Hospital, Tianjin Medical University, 6 Jizhao Rd, Tianjin, 300350, China.
Lei XiangDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Huanhu Hospital, Tianjin Medical University, 6 Jizhao Rd, Tianjin, 300350, China.
Wei YueDepartment of Neurology, Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases, Clinical College of Neurology, Neurosurgery, and Neurorehabilitation, Huanhu Hospital, Tianjin Medical University, 6 Jizhao Rd, Tianjin, 300350, China. hhyuewei2021@163.com.

Funding

Tianjin Key Medical Discipline(Specialty) Construction Project TJYXZDXK-052B
6 · The paper itself

Abstract

introductionDepression after a stroke is the most frequent and burdensome neuropsychiatric post-stroke complication. This study aimed to determine the relationship between post-stroke depression (PSD) and the levels of homocysteine (HCY) in patients with spontaneous intracerebral hemorrhage (SICH).

methodWe collected data from patients with hemorrhagic stroke (HS) admitted to the hospital and recorded their demographic and clinical characteristics. We also searched for information regarding HAM-D

resultA total of 1,852 patients were included. 642 (34.7%) patients with PSD and 598 (32.3%) patients with HHcy, 364 (19.7%) patients with both conditions. A link between depression and low HCY level has similarly been found in patients with HS (OR, 1.549; 95% CI, 1.358-1.768). Additionally, left-sided stroke, anterior circulatory stroke, intraventricular hemorrhage, symptoms of paralysis or dysarthria, and higher NIHSS scores occurred more often in the PSD group. Compared to the antidepressant medications (ADM) group, HAM-D

conclusionOn the basis of our data, PSD was significantly more frequent in patients with HHcy in patients with SICH at the acute phase. The location of hemorrhage and the severity of the disease are significantly correlated with the incidence of PSD. Oral doses of folic acid and ADM showed significant improvements in the HAM-D

Indexed as

Cerebral HemorrhageDepressionHomocysteineStrokeAgedAntidepressive AgentsFemaleFolic AcidHumansHyperhomocysteinemiaMaleMiddle AgedAntidepressive AgentsFolic AcidHomocysteineFolic acidHomocysteineIntracerebral hemorrhagePost-stroke depressionTreatment

Identifiers

PMID42104297
PMCPMC13321771

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.