Astrocyte-derived miR-124 impairs glioma cell volume regulation and migration by reducing Ca

Myriam Catalano, Arianna Rinaldi, Angela Di Battista, Cristina Limatola, Luigi Catacuzzeno, Antonio Michelucci

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Article in Cellular and molecular life sciences : CMLS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

6 authors.

Myriam CatalanoDepartment of Physiology and Pharmacology, Laboratory affiliated to Istituto Pasteur Italia, Sapienza University, Rome, Italy. Myriam.Catalano@uniroma1.it.

Arianna RinaldiDepartment of Physiology and Pharmacology, Laboratory affiliated to Istituto Pasteur Italia, Sapienza University, Rome, Italy.

Angela Di BattistaDepartment of Chemistry, Biology, and Biotechnology, University of Perugia, Perugia, Italy.

Cristina LimatolaDepartment of Physiology and Pharmacology, Laboratory affiliated to Istituto Pasteur Italia, Sapienza University, Rome, Italy.

Luigi CatacuzzenoDepartment of Chemistry, Biology, and Biotechnology, University of Perugia, Perugia, Italy. luigi.catacuzzeno@unipg.it.

Antonio MichelucciDepartment of Chemistry, Biology, and Biotechnology, University of Perugia, Perugia, Italy. antonio.michelucci@unipg.it.ORCID http://orcid.org/0000-0002-0720-3009

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Astrocytes play a key role in regulating glioma cell volume, a major determinant of tumor invasiveness. We previously reported that astrocyte-derived extracellular vesicles (ADEVs) transfer microRNA miR-124 to murine glioma cells, impairing cell volume regulation and reducing the functional expression of volume-regulated anion channel (VRAC). Here, we identify the intermediate-conductance Ca

Indexed as

AstrocytesCell MovementGene Expression Regulation, NeoplasticGliomaIntermediate-Conductance Calcium-Activated Potassium ChannelsMicroRNAsAnimalsCalcium SignalingCell Line, TumorCell SizeEndoplasmic ReticulumMiceRyanodine Receptor Calcium Release ChannelIntermediate-Conductance Calcium-Activated Potassium ChannelsMicroRNAsMirn124 microRNA, mouseRyanodine Receptor Calcium Release ChannelAstrocyte-derived extracellular vesiclesCell volume regulationER Ca2+ signalingERK1/2GlioblastomaGliomaIntermediate-conductance Ca2+-activated K+ channelIP3R3MigrationmiR-124RyR1VRAC

Identifiers

PMID42104151

DOI10.1007/s00018-026-06217-x

PMCPMC13323428

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.