Evidence map›Paper›PMID 42104014›Full record

ArticleExperimental & molecular medicine2026

TopBP1 orchestrates PU.1-IRF8 transcriptional programming of dendritic cell differentiation and Flt3L-driven tumor immunity.

Min-Suk Cha, Myeong-Ho Kang, Jinjoo Lee, JungHyub Hong, Yu Sun Jeong, Yoe-Sik Bae, Ho Lee, Seok-Hee Park, Yong-Soo Bae

Abstract read
In one paragraph

Article in Experimental & molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Min-Suk ChaDepartment of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.
Myeong-Ho KangDepartment of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.
Jinjoo LeeDepartment of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.
JungHyub HongDepartment of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.
Yu Sun JeongDepartment of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.
Yoe-Sik BaeDepartment of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea.ORCID http://orcid.org/0000-0002-6198-4512
Ho LeeDivision of Convergence Technology, Research Institute, National Cancer Center, Goyang, Republic of Korea.ORCID http://orcid.org/0000-0001-5573-742X
Seok-Hee ParkDepartment of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea. parks@skku.edu.ORCID http://orcid.org/0000-0002-6210-4927
Yong-Soo BaeDepartment of Biological Sciences, Sungkyunkwan University, Suwon, Republic of Korea. ysbae04@skku.edu.

Funding

National Research Foundation of Korea (NRF) RS202400348626
6 · The paper itself

Abstract

DNA topoisomerase II-binding protein 1 (TopBP1) plays a critical role in V(D)J recombination and DNA damage repair during B and T cell development. However, its role in the development of conventional dendritic cells (cDCs) remains unexplored. Mice with DC-specific depletion of TopBP1 (TopBP1

Indexed as

Cell DifferentiationDendritic CellsInterferon Regulatory Factor-8Membrane ProteinsNeoplasmsProto-Oncogene Protein Spi-1AnimalsMiceMice, Inbred C57BLMice, Knockoutflt3 ligand proteinInterferon Regulatory Factor-8Membrane ProteinsProto-Oncogene Protein Spi-1

Identifiers

PMID42104014
PMCPMC13234112

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.