Article in EMBO reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Katherine R Balka *Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Olivia R Lamb *Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Rajan Venkatraman *Department of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Zoe MagillDepartment of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0003-2743-0804
Le T HoangDepartment of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0009-0005-9350-6880
Ryker DumbrillDepartment of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0009-0003-4399-4279
Kate McArthurDepartment of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-8838-4146
Nicole A de WeerdCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.ORCID 0000-0002-7985-189X
Paul J HertzogCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Peter J CrackDepartment of Biochemistry and Pharmacology, The University of Melbourne, Parkville, VIC, Australia.
Linda M WakimDepartment of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Parkville, VIC, Australia.
Kim L Good-JacobsonDepartment of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0003-1891-7274
Mireille H LahoudDepartment of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Meredith O'KeeffeDepartment of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.ORCID 0000-0002-0779-4654
Dominic De NardoDepartment of Biochemistry and Molecular Biology, Immunity Program, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. dominic.denardo@monash.edu.ORCID 0000-0002-7045-4695
Funding
Australian and New Zealand Society for Immunology (ASI) Breakthrough Immunology AwardDepartment of Education and Training | Australian Research Council (ARC) DP210103122DHAC | National Health and Medical Research Council (NHMRC) 2020613DHAC | National Health and Medical Research Council (NHMRC) 2033037DHAC | National Health and Medical Research Council (NHMRC) 2047696European Molecular Biology Organization (EMBO) ALTF 112-2024Monash University (MU) Australian Government Research Training Program ScholarshipsMU | Faculty of Medicine, Nursing and Health Sciences, Monash University (FMNHS) Monash Silver Jubilee Postgraduate Research scholarship/ Monash Graduate Excellence Scholarship
6 · The paper itself
Abstract
STING is an important component in the host innate immune system where its activation by cyclic dinucleotides culminates in the production of interferons and pro-inflammatory cytokines that mediate host defence against infection. While the mechanisms that govern STING-induced interferon production have been comprehensively characterised, how pro-inflammatory cytokines are produced downstream of STING remains less understood. Here we discover that IRF3 is critical for effective STING-mediated inflammatory cytokine production from macrophages as those lacking IRF3 display significant defects. Interestingly, the loss of IRF3 does not impact the activation of the prominent pro-inflammatory transcription factor, NF-κB, but rather affects the AP-1 transcriptional complex. We further discover the role of IRF3 in STING inflammatory responses is independent of its phosphorylation and distinct from its role as a transcription factor for induction of type I interferons. This additional activity of IRF3 is dependent on its recruitment to the previously defined IRF3 binding motif within the C-terminal tail of STING. Hence, our findings reveal an unexpected noncanonical function of IRF3 that is critical for mediating STING-induced pro-inflammatory cytokines from macrophages.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Noncanonical IRF3 function mediates STING-dependent pro-inflammatory cytokine production in macrophages. · full record | OpenQuestion