Evidence map›Paper›PMID 42103970›Full record

ArticleLangenbeck's archives of surgery2026

Impact of preoperative skeletal muscle mass on the healing time of postoperative pancreatic fistula after pancreaticoduodenectomy.

Takuro Takeuchi, Yoshito Tomimaru, Hirofumi Akita, Yosuke Mukai, Kazuki Sasaki, Shinichiro Hasegawa, Daisaku Yamada, Takehiro Noda, Yuichiro Doki, Hidetoshi Eguchi

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In one paragraph

Article in Langenbeck's archives of surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Takuro TakeuchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamadaoka,, Suita, Osaka, 565-0871, Japan.
Yoshito TomimaruDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamadaoka,, Suita, Osaka, 565-0871, Japan.
Hirofumi AkitaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamadaoka,, Suita, Osaka, 565-0871, Japan. hakita@gesurg.med.osaka-u.ac.jp.
Yosuke MukaiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamadaoka,, Suita, Osaka, 565-0871, Japan.
Kazuki SasakiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamadaoka,, Suita, Osaka, 565-0871, Japan.
Shinichiro HasegawaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamadaoka,, Suita, Osaka, 565-0871, Japan.
Daisaku YamadaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamadaoka,, Suita, Osaka, 565-0871, Japan.
Takehiro NodaDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamadaoka,, Suita, Osaka, 565-0871, Japan.
Yuichiro DokiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamadaoka,, Suita, Osaka, 565-0871, Japan.
Hidetoshi EguchiDepartment of Gastroenterological Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E2, Yamadaoka,, Suita, Osaka, 565-0871, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPostoperative pancreatic fistula (POPF) is a serious complication following pancreaticoduodenectomy (PD). While numerous studies have investigated POPF incidence and risk factors, few have focused on POPF healing time (POPF-HT). Skeletal muscle mass has been increasingly recognized as an endocrine organ involved in interorgan communication. The aim of this study was to evaluate how skeletal muscle mass influenced the healing time of POPF after PD.

methodsThis investigation included patients who developed POPF of grade B-C after PD with pancreaticojejunostomy during the study period. POPF-HT was defined as the duration from the date of PD to the removal of all drains placed for POPF treatment. Skeletal muscle mass was assessed based on preoperative computed tomography images. Clinical factors associated with POPF-HT were analyzed, including skeletal muscle index (SMI).

resultsThe mean POPF-HT was 40 ± 15 days (median: 37 days; range: 21-105 days). Compared to those with high SMI, patients with low SMI had a significantly longer POPF-HT (46 ± 18 days vs. 37 ± 11 days, p = 0.0101). In univariate analysis, low SMI was significantly associated with prolonged POPF-HT (hazard ratio: 0.5655, 95% confidence interval: 0.3687-0.8673, p = 0.0090). Kaplan-Meier curves confirmed that patients with low SMI exhibited significantly delayed cumulative POPF healing (p = 0.0065).

conclusionDecreased skeletal muscle mass is significantly associated with prolonged POPF-HT after PD. Therefore, preoperative SMI may serve as a potentially modifiable factor associated with POPF-HT.

Indexed as

Muscle, SkeletalPancreatic FistulaPancreaticoduodenectomyPostoperative ComplicationsWound HealingAgedFemaleHumansMaleMiddle AgedRetrospective StudiesRisk FactorsTime FactorsTomography, X-Ray ComputedPancreatic fistulaPancreaticoduodenectomySkeletal muscleSMI

Identifiers

PMID42103970
PMCPMC13323506

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.