Evidence map›Paper›PMID 42103737›Full record

ArticleCell death & disease2026

MECP2 mutations disrupt pluripotent stem cell fate through remodeling of the three-dimensional genome.

Jing Zhou, Yizhuo Che, Xintao Jing, Fang Li, Hang Peng, Yuchun Liu, Li Cao, Jinyuan Zhang, Xiaofei Wang, Jia Zhang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jing ZhouDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Yizhuo CheFaculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, China.
Xintao JingDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Fang LiDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Hang PengDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Yuchun LiuFaculty of Electronic and Information Engineering, Xi'an Jiaotong University, Xi'an, China.
Li CaoDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Jinyuan ZhangDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Xiaofei WangDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China.
Jia ZhangDepartment of Thoracic Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Aihong GuoDepartment of Neurology, Xianyang Hospital of Yan'an University, Xianyang, China.
Dongdong TongDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China. tongdd@xjtu.edu.cn.ORCID http://orcid.org/0000-0002-2716-5783
Bingju WangDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China. wangbingju2021@163.com.ORCID http://orcid.org/0009-0006-4752-5236
Chen HuangDepartment of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University, Xi'an, China. hchen@xjtu.edu.cn.ORCID http://orcid.org/0000-0002-0355-3036

Funding

Education Department of Jiangxi Province (Department of Education of Jiangxi Province) GJJ2503408National Natural Science Foundation of China (National Science Foundation of China) 32271006
6 · The paper itself

Abstract

Mutations in the MECP2 gene are the primary cause of Rett syndrome, yet their mechanistic roles during early developmental stages remain poorly understood. In this study, CRISPR-Cas9 technology was applied to generate three loss-of-function mutations in male induced pluripotent stem cells (iPSCs), namely MECP2

Indexed as

Induced Pluripotent Stem CellsMethyl-CpG-Binding Protein 2MutationPluripotent Stem CellsAnimalsCell DifferentiationChromatinChromatin Assembly and DisassemblyEmbryoid BodiesGenomeHumansMaleMiceOctamer Transcription Factor-3Rett SyndromeSOXB1 Transcription FactorsChromatinMethyl-CpG-Binding Protein 2Octamer Transcription Factor-3SOXB1 Transcription Factors

Identifiers

PMID42103737
PMCPMC13324534

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.