ArticleTranslational psychiatry2026
Distinct sensory atypicalities bridge the gap between brain chemistry and motor dysfunction in autism.
Mingrun Shi, Jason L He, Helen Powell, Oliver Lack, Georg Oeltzschner, Alyssa Deronda, Deana Crocetti, Ericka L Wodka, Richard A Edden, Jonathan O'Muircheartaigh and 2 more
Abstract read
In one paragraphArticle in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Helen PowellDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Deana CrocettiCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, US.
Ericka L WodkaCenter for Autism Science, Services and Innovation, Kennedy Krieger Institute, Baltimore, MD, US.
Richard A EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, US.
Jonathan O'MuircheartaighDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Stewart H MostofskyCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, US.
Nicolaas A J PutsDepartment of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK. nicolaas.puts@kcl.ac.uk.ORCID http://orcid.org/0000-0003-1024-1927 Funding
Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9MTRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9MAnomalous Motor Physiology In ADHDR01MH078160 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2006 to 2024
$5.8MSomatosensory Inhibitory Dysfunction in Autism Spectrum Disorder.R01MH106564 · NIMH · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2016 to 2020
$2.5MA Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum DisorderR00MH107719 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PUTS, NICOLAAS · 2018 to 2019
$492kMeasuring Altered Glutathione in Children with Autism Spectrum DisorderR21HD100869 · NICHD · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2020 to 2021
$463kNICHD NIH HHS P50 HD103538U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) P41EB031771U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R00MH107719U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH078160U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R01MH106564U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R21HD100869
6 · The paper itselfAbstract
Sensory and motor difficulties are common in autism. Altered excitation-inhibition (E-I) balance is a putative framework for understanding atypical sensory and motor function. We investigated whether sensory differences of autism mediate motor difficulties of autism via differences in E-I balance. 106 children were included in the study (Autism n = 44, Typical development children (TDC) n = 62, age 10.32 ± 1.49). E-I balance was assessed through magnetic resonance spectroscopy (MRS), quantifying Glutamate and Glutamine (Glx) and Gamma-Aminobutyric Acid (GABA) in primary sensorimotor cortex (SM1) and thalamus (Thal). Sensory function was evaluated using both objective vibrotactile perceptual sensitivity assessments and subjective parent ratings via the Sensory Experience Questionnaire (SEQ). Motor ability was assessed objectively through the Movement Assessment Battery for Children-second edition (MABC-2) and the Physical and Neurological Examination for Subtle Signs (PANESS). Our findings reveal that lower sensory reactivity and lower tactile thresholds are both predictive of better motor ability (R
Indexed as
Autistic DisorderBrain ChemistrySensorimotor CortexThalamusChildFemalegamma-Aminobutyric AcidGlutamic AcidGlutamineHumansMagnetic Resonance SpectroscopyMalegamma-Aminobutyric AcidGlutamic AcidGlutamine
Identifiers
PMID42103716
PMCPMC13324517
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390