Evidence map›Paper›PMID 42103567›Full record

ReviewTrends in cell biology2026

Stress-induced breakup: tRNA-derived small RNAs in biology.

Guoping Li, Tian Hao, Pavel Ivanov, Saumya Das

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guoping LiCardiovascular Research Center, Heart and Vascular Institute, Massachusetts General Brigham, Harvard Medical School, Boston, MA, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Brigham, Harvard Medical School, Boston, MA, USA. Electronic address: gli21@mgh.harvard.edu.
Tian HaoCardiovascular Research Center, Heart and Vascular Institute, Massachusetts General Brigham, Harvard Medical School, Boston, MA, USA; Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Brigham, Harvard Medical School, Boston, MA, USA.
Pavel IvanovDivision of Rheumatology, Inflammation and Immunity, Department of Medicine, Massachusetts General Brigham, Harvard Medical School, Boston, MA, USA.
Saumya DasCardiovascular Research Center, Heart and Vascular Institute, Massachusetts General Brigham, Harvard Medical School, Boston, MA, USA. Electronic address: sdas@mgh.harvard.edu.

Funding

Functional role and therapeutic targeting of exosomes and extracellular RNA biomarkers in heart failureR35HL150807 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Saumya Das · 2020 to 2026
$6.7M
Stress-induced tRNA-derived small RNAs in cardiac fibrosisR01HL174709 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Guoping Li · 2025 to 2026
$1.4M
Engineering RNA editing tools for the generation of functional tRNA-derived small RNAs in the kidneyR21DK137432 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI BONVENTRE, JOSEPH VINCENT, DAS, SAUMYA · 2023 to 2023
$332k
NHLBI NIH HHS R01 HL174709NHLBI NIH HHS R35 HL150807NIDDK NIH HHS R21 DK137432
6 · The paper itself

Abstract

The cleavage of full-length transfer RNAs generates functional small RNAs called tRNA-derived small RNAs (tsRNAs or tDRs). This review synthesizes recent advances in our understanding of tDRs, summarizing the molecular mechanisms of their biogenesis and illuminating their function in modulating pathways important in the cellular stress response. Key structural motifs appear to be critical determinants of tDR function by modulating binding to partner proteins and RNAs. Finally, the role of tDRs in the pathogenesis of various diseases and the feasibility of targeting them with novel molecular tools are discussed. In summary, tDRs are an evolutionarily conserved class of small RNAs important for the cellular response to stress and are emerging as a promising target for human diseases.

Indexed as

noncoding small RNAsRNA therapeuticsstress responsetRNA fragments

Identifiers

PMID42103567
PMCPMC13157974

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.