Evidence map›Paper›PMID 42103483›Full record

ArticleThe European journal of neuroscience2026

Oxytocin Neuron-Specific CAPS2 Deficiency in Mice Impairs Hippocampal Plasticity and Long-Term Memory Through Reduced ERK Phosphorylation in the Ventral hippocampus.

Wakana Nagano, Junpei Takahashi, Tsugumi Yamauchi, Daisuke Yamada, Yoshitake Sano, Teiichi Furuichi, Akiyoshi Saitoh

Abstract read
In one paragraph

Article in The European journal of neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wakana NaganoLaboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.
Junpei TakahashiLaboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.
Tsugumi YamauchiLaboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.
Daisuke YamadaDepartment of Physiology II, School of Medicine, Kanazawa Medical University, Kanazawa, Japan.
Yoshitake SanoDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Chiba, Japan.
Teiichi FuruichiDepartment of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Chiba, Japan.
Akiyoshi SaitohLaboratory of Pharmacology, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Tokyo, Japan.ORCID 0000-0001-8617-2441

Funding

JSPS Fellows JP 21J20036JSPS Fellows JP 26KJ2003
6 · The paper itself

Abstract

Oxytocin (OXT), a neuropeptide produced in the paraventricular nucleus (PVN) of the hypothalamus, regulates social behaviour, stress responses, and memory. Our previous studies demonstrated that intracerebroventricular administration of OXT ameliorates amyloid-β-induced cognitive deficits and that selective activation of PVN OXT neurons enhances memory performance. These findings suggest that endogenous OXT secretion is essential for normal memory processing and that its impairment may lead to cognitive dysfunction. To test this hypothesis, we generated oxytocin neuron-specific conditional knockout (cKO) mice for the Ca

Indexed as

Calcium-Binding ProteinsHippocampusMemory, Long-TermNerve Tissue ProteinsNeuronal PlasticityNeuronsOxytocinAnimalsExtracellular Signal-Regulated MAP KinasesLong-Term PotentiationMaleMiceMice, Inbred C57BLMice, KnockoutPhosphorylationRecognition, PsychologyCalcium-Binding ProteinsCAPS2 protein, mouseExtracellular Signal-Regulated MAP KinasesNerve Tissue ProteinsOxytocinCa2+‐dependent activator protein for secretioncognitive functionlearningmemoryoxytocin

Identifiers

PMID42103483
PMCPMC13156022

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.