Evidence map›Paper›PMID 42103379›Full record

Trial reportBMJ open2026

Prevalence and types of anxiety disorders among patients with cardiac conditions and elevated HADS-A scores: findings from the initial screening phase of the Heart and Mind trial in Denmark.

Selina Kikkenborg Berg, Line Ryberg Rasmussen, Charlotte Brun Thorup, Trine Bernholdt Rasmussen, Anne Vinggaard Christensen, Cecilie Bech Hammer, Martin Balslev Jorgensen, Jesper Hastrup Svendsen, Signe Stelling Risom, Carsten Juul and 1 more

Registry-linked trialAbstract readRandomized Controlled Trial
In one paragraph

Trial report in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04582734 (Screening and Intervention Reducing Anxiety in Patients With Cardiac Disease), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04582734 naunknown statusnot on this map

Screening and Intervention Reducing Anxiety in Patients With Cardiac Disease: The Heart & Mind Trial

TypeinterventionalSponsorRigshospitalet, DenmarkRan2021 to 2024Enrolled336ConditionsCognitive Therapy, Anxiety Disorders, Heart DiseasesArmsCognitive-behavioural therapy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Selina Kikkenborg BergDepartment of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Capital Region of Denmark, Denmark selina@rh.dk.ORCID http://orcid.org/0000-0002-9493-954X
Line Ryberg RasmussenDepartment of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Capital Region of Denmark, Denmark.ORCID http://orcid.org/0000-0001-9317-7662
Charlotte Brun ThorupDepartment of Cardiology and Department of Cardiothoracic Surgery, Aalborg University Hospital, Aalborg, Denmark.
Trine Bernholdt RasmussenDepartment of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Capital Region of Denmark, Denmark.
Anne Vinggaard ChristensenDepartment of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Capital Region of Denmark, Denmark.
Cecilie Bech HammerDepartment of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Capital Region of Denmark, Denmark.
Martin Balslev JorgensenDepartment of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Capital Region of Denmark, Denmark.ORCID http://orcid.org/0000-0002-1321-8901
Jesper Hastrup SvendsenDepartment of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Capital Region of Denmark, Denmark.
Signe Stelling RisomDepartment of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Capital Region of Denmark, Denmark.
Carsten JuulHeypeople, Copenhagen, Denmark.
Inge SchjødtDepartment of Cardiology, Aarhus University Hospital, Aarhus, Central Denmark Region, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo identify whether patients with arrhythmia, heart failure or ischaemic heart disease presenting with anxiety symptoms measured by the Hospital Anxiety and Depression Scale (HADS) have identifiable anxiety according to the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders (SCID) and, if so, which type of anxiety disorder based on the SCID.

designInitial screening data from the Heart and Mind randomised clinical trial.

settingPatients with arrhythmia, heart failure or ischaemic heart disease were screened using HADS, and patients with a HADS-anxiety (HADS-A) score≥8 were invited to participate. Participants were interviewed by trained cardiac nurses using the SCID to determine whether they met the criteria for anxiety and, if so, the type of anxiety disorder.

resultsOf the 7816 patients who completed the HADS questionnaire, 1803 (23%) had a HADS-A score≥8. Among these, 398 (22%) agreed to the SCID interview, and 336 (84%) met the diagnostic criteria for an anxiety disorder. The mean age was 61 years, with 40% being female. The mean HADS-A score was 11.3 (SD=2.7). The most common types of anxiety were generalised anxiety disorder (61%), panic disorder (23%) and specific phobia (8%).

conclusionsThe majority of individuals identified by the instrument also met the diagnostic criteria for an anxiety disorder. Generalised anxiety disorder and panic disorder were the most prevalent subtypes. Anxiety was common across the cardiac population, underscoring the need for routine assessment and targeted intervention in clinical practice. TRIAL REGISTRATION NUMBER: NCT04582734.

Indexed as

Anxiety DisordersArrhythmias, CardiacHeart FailureMyocardial IschemiaAgedDenmarkFemaleGeneralized Anxiety DisorderHumansMaleMiddle AgedPanic DisorderPrevalencePsychiatric Status Rating ScalesSurveys and QuestionnairesAnxiety disordersCardiovascular DiseaseHeart failureIschaemic heart diseaseMENTAL HEALTH

Identifiers

PMID42103379
PMCPMC13157784

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.