Evidence map›Paper›PMID 42103354›Full record

ArticleJournal for immunotherapy of cancer2026

PSCA CAR Vδ1 T cells: a safer off-the-shelf CAR T therapy for pancreatic cancer?

Joseph A Fraietta, Jason J Lohmueller

Abstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joseph A FraiettaDepartment of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA jfrai@upenn.edu jasonloh@pitt.edu.ORCID http://orcid.org/0000-0001-7900-8993
Jason J LohmuellerDivision of Surgical Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA jfrai@upenn.edu jasonloh@pitt.edu.ORCID http://orcid.org/0000-0001-6089-9992

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic cancer remains among the deadliest malignancies, with a 5-year survival of ~13%. Chimeric antigen receptor (CAR) T -cell therapy offers hope, but conventional αβ T cells can trigger severe toxicities, including graft-versus-host disease (GvHD) when used for allogeneic therapy. By contrast, γδ T cells recognize tumors without MHCmajor histocompatibility complex restriction and are unlikely to cause GvHD, making them attractive candidates for "off-the-shelf" immunotherapy. Li

Indexed as

Antigens, NeoplasmImmunotherapy, AdoptiveNeoplasm ProteinsPancreatic NeoplasmsReceptors, Antigen, T-Cell, gamma-deltaReceptors, Chimeric AntigenT-LymphocytesAnimalsGPI-Linked ProteinsHumansAntigens, NeoplasmGPI-Linked ProteinsNeoplasm ProteinsPSCA protein, humanReceptors, Antigen, T-Cell, gamma-deltaReceptors, Chimeric AntigenChimeric antigen receptor - CARGastrointestinal CancerGraft versus host disease - GVHDImmunotherapyT cell

Identifiers

PMID42103354
PMCPMC13157800

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.