Evidence map›Paper›PMID 42103230›Full record

ArticleThe Journal of biological chemistry2026

TRIM25 enhances hypoxia signaling by catalyzing K11-linked polyubiquitination and stabilization of HIF-α.

Ziyi Li, Jun Li, Zhi Li, Rui Wang, Le Yuan, Yanan Song, Yanyi Wang, Runkun Yan, Fuxiang Lai, Jing Wang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ziyi LiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, PR China; University of Chinese Academy of Sciences, Beijing, PR China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, PR China.
Jun LiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, PR China; University of Chinese Academy of Sciences, Beijing, PR China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, PR China.
Zhi LiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, PR China; University of Chinese Academy of Sciences, Beijing, PR China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, PR China.
Rui WangState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, PR China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, PR China.
Le YuanState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, PR China; University of Chinese Academy of Sciences, Beijing, PR China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, PR China.
Yanan SongState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, PR China; University of Chinese Academy of Sciences, Beijing, PR China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, PR China.
Yanyi WangState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, PR China; University of Chinese Academy of Sciences, Beijing, PR China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, PR China.
Runkun YanState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, PR China; University of Chinese Academy of Sciences, Beijing, PR China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, PR China.
Fuxiang LaiState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, PR China; University of Chinese Academy of Sciences, Beijing, PR China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, PR China.
Jing WangState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, PR China; University of Chinese Academy of Sciences, Beijing, PR China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, PR China.
Wuhan XiaoState Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences; Hubei Hongshan Laboratory, Wuhan, PR China; Laboratory for Marine Biology and Biotechnology, Qingdao Marine Science and Technology Center, Qingdao, PR China; University of Chinese Academy of Sciences, Beijing, PR China; The Innovation of Seed Design, Chinese Academy of Sciences, Wuhan, PR China. Electronic address: w-xiao@ihb.ac.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TRIM25 is an E3 ubiquitin ligase involved in various cellular processes due to its enzymatic activity. In particular, it plays a role in antiviral innate immunity. Here, we demonstrate that TRIM25 modulates hypoxia signaling. TRIM25 interacts with HIF-1α and HIF-2α, stabilizing them. TRIM25 catalyzes K11-linked polyubiquitination of HIF-1α at K719 and K721 and of HIF-2α at K709. This results in the stabilization of the proteins and enhanced hypoxia signaling. Moreover, TRIM25-mediated augmentation of hypoxia signaling depends on HIF-1α. Trim25-deficient mice are more sensitive to hypoxia, and zebrafish lacking trim25 show a similar phenotype. These data reveal TRIM25's role in regulating hypoxia signaling and provide insight into a new mechanism that modulates the stabilization and activity of HIF-1α and HIF-2α.

Indexed as

HypoxiaHypoxia-Inducible Factor 1, alpha SubunitLysineSignal TransductionTranscription FactorsTripartite Motif ProteinsUbiquitin-Protein LigasesAnimalsBasic Helix-Loop-Helix ProteinsCell HypoxiaEndothelial PAS Domain-Containing Protein 1HEK293 CellsHumansMiceProtein StabilityUbiquitinationBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1Hypoxia-Inducible Factor 1, alpha SubunitLysineTranscription FactorsTRIM25 protein, humanTripartite Motif ProteinsUbiquitin-Protein LigasesHIF-αhypoxia signalingTRIM25ubiquitination

Identifiers

PMID42103230
PMCPMC13241728

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.