OTOP2 proton channel couples luminal pH sensing to intestinal immune homeostasis.

Weihui Yan, Ying Wang, Hongxia Zhao, Shicheng Peng, Ying Lu, Bo Wu, Yongtao Xiao

Abstract read

In one paragraph

Article in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Weihui YanDivision of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.

Ying WangDivision of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.

Hongxia ZhaoDivision of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.

Shicheng PengShanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China; Shanghai Institute of Pediatric Research, Shanghai, China.

Ying LuShanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China; Shanghai Institute of Pediatric Research, Shanghai, China.

Bo WuDivision of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China.

Yongtao XiaoDivision of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Pediatric Gastroenterology and Nutrition, Shanghai, China; Shanghai Institute of Pediatric Research, Shanghai, China; Department of Pediatric Surgery, Hangzhou Children's Hospital, Hangzhou, Zhejiang, China. Electronic address: yongtaoxiao1982@sjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular acidification is a hallmark of the inflamed intestinal tract in individuals with inflammatory bowel disease (IBD). The proton channel Otopetrin-2 (OTOP2), which is enriched in intestinal tissues, becomes dysregulated during inflammation. However, the specific role of OTOP2 in IBD pathogenesis remains unclear. In this study, we demonstrate a significant reduction of OTOP2 mRNA and protein in the inflamed mucosa of pediatric patients with IBD, which inversely correlates with disease progression. Otop2 knockout (Otop2

Indexed as

HomeostasisInflammatory Bowel DiseasesIntestinal MucosaAnimalsColitisDextran SulfateHumansHydrogen-Ion ConcentrationIntestinal Barrier FunctionMiceMice, Inbred C57BLMice, KnockoutDextran Sulfategoblet cellsintestinal barrierOTOP2Paneth cellspH sensing

Identifiers

PMID42103221

DOI10.1016/j.jbc.2026.113105

PMCPMC13241748

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.