Methylation marks breast cancer metastasis: The roles of m

Brock A Humphries, Zhishan Wang, Chengfeng Yang

Abstract readReview

In one paragraph

Review in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brock A HumphriesCenter for Molecular Imaging, Department of Radiology, University of Michigan, Ann Arbor, Michigan, USA. Electronic address: brhu@med.umich.edu.

Zhishan WangStony Brook Cancer Center, Stony Brook University, New York, USA; Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA.

Chengfeng YangStony Brook Cancer Center, Stony Brook University, New York, USA; Department of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, USA. Electronic address: chengfeng.yang@stonybrook.edu.

Funding

Dysregulations of functional RNA modifications and hexavalent chromium lungcarcinogenesisR01ES032787 · NIEHS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Chengfeng Yang · 2022 to 2026

$2.1M

MGMT DOWN-REGULATION IN THE CARCINOGENICITY OF HEXAVALENT CHROMIUMR01ES029496 · NIEHS · UNIVERSITY OF KENTUCKY · PI WANG, ZHISHAN · 2019 to 2023

$1.7M

NIEHS NIH HHS R01 ES029496NIEHS NIH HHS R01 ES032787

6 · The paper itself

Abstract

Breast cancer is the most commonly diagnosed cancer and a leading cause of death in women, with metastasis accounting for most of these fatalities. The mechanism of breast cancer metastasis has not been well understood. Recent research shows that chemical modifications added to RNA molecules after they are made, specifically the addition of a methyl group on the N

Indexed as

AdenosineBreast NeoplasmsMicroRNAsRNA, Long NoncodingEpitranscriptomeFemaleHumansNeoplasm MetastasisRNA MethylationAdenosineMicroRNAsN-methyladenosineRNA, Long Noncodingbreast cancer metastasisepitranscriptomicslong noncoding RNAmicroRNARNA m(6)A methylation

Identifiers

PMID42103211

DOI10.1016/j.jbc.2026.113127

PMCPMC13254601

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.