Evidence map›Paper›PMID 42103073›Full record

ArticleCancer letters2026

Human neural stem cell-derived extracellular vesicles improve cognitive function following glioma chemoradiation therapy.

Casey Hudson, Robert P Krattli, Sanad M El-Khatib, Arya R Vagadia, An H Do, Shreya Madan, Manal T Usmani, Tracy Nguyen, Devyani Swami, Katja M Piltti and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Casey HudsonDepartment of Anatomy & Neurobiology, University of California, Irvine, United States. Electronic address: hudsonc3@uci.edu.
Robert P KrattliDepartment of Anatomy & Neurobiology, University of California, Irvine, United States. Electronic address: krattlir@uci.edu.
Sanad M El-KhatibDepartment of Anatomy & Neurobiology, University of California, Irvine, United States. Electronic address: smelkhat@uci.edu.
Arya R VagadiaDepartment of Anatomy & Neurobiology, University of California, Irvine, United States. Electronic address: arya.vagadia@gmail.com.
An H DoDepartment of Anatomy & Neurobiology, University of California, Irvine, United States. Electronic address: ahdo2@uci.edu.
Shreya MadanDepartment of Anatomy & Neurobiology, University of California, Irvine, United States. Electronic address: smadan2@uci.edu.
Manal T UsmaniDepartment of Anatomy & Neurobiology, University of California, Irvine, United States. Electronic address: manal.usmani@gmail.com.
Tracy NguyenDepartment of Anatomy & Neurobiology, University of California, Irvine, United States. Electronic address: tracyn14@hs.uci.edu.
Devyani SwamiDepartment of Anatomy & Neurobiology, University of California, Irvine, United States. Electronic address: swamid@uci.edu.
Katja M PilttiDepartment of Physical Medicine & Rehabilitation, University of California, Irvine, United States. Electronic address: kpiltti@uci.edu.
Leslie M ThompsonDepartment of Psychiatry & Human Behavior, University of California, Irvine, United States. Electronic address: lmthomps@hs.uci.edu.
Brian J CummingsDepartment of Physical Medicine & Rehabilitation, University of California, Irvine, United States. Electronic address: cummings@uci.edu.
Aileen J AndersonDepartment of Physical Medicine & Rehabilitation, University of California, Irvine, United States. Electronic address: aja@uci.edu.
Munjal M AcharyaDepartment of Anatomy & Neurobiology, Department of Radiation Oncology, University of California, Irvine, United States. Electronic address: macharya@uci.edu.

Funding

Univ.of Calif., Irvine Cancer Center Support GrantP30CA062203 · NCI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joel E Milam · 1994 to 2026
$57.9M
NCI NIH HHS P30 CA062203
6 · The paper itself

Abstract

Cranial radiation therapy (RT) with concomitant and adjuvant temozolomide (TMZ; Stupp protocol) prolongs glioma survival but frequently results in persistent cognitive impairment. Human neural stem cell (hNSC)-derived extracellular vesicles (EVs) are a promising acellular therapy whose bioactive cargo can modulate neuroinflammation and synaptic integrity. We evaluated two EVs derived from GMP-grade hNSCs (Shef6 and UCI-191) in syngeneic glioma-bearing and non-tumor adult mice treated with fractionated cranial RT (3 × 8.67 Gy) together with concomitant low-dose (25 mg/kg) and adjuvant high-dose (66.7 mg/kg, intraperitoneal) TMZ. EV administration improved memory performance in RT-TMZ-exposed mice and, notably, Shef6-EVs also extended survival in glioma-bearing mice in the absence of chemoradiotherapy. Immunofluorescence analyses demonstrated attenuated gliosis and preservation of synaptic integrity in EV-treated RT-TMZ-exposed brains, while transcriptomic profiling identified distinct neuroprotective gene expression pathways associated with each EV source. Critically, neither Shef6 nor UCI-191 EVs diminished or interfered with the anti-tumor efficacy of RT-TMZ. These data support hNSC-derived EVs as a translational strategy to mitigate treatment-related neurotoxicity while preserving oncologic benefit in a clinically relevant glioma model.

Indexed as

Brain NeoplasmsChemoradiotherapyCognitionExtracellular VesiclesGliomaNeural Stem CellsAnimalsCell Line, TumorCognitive EnhancementCranial IrradiationHumansMiceTemozolomideTemozolomideChemotherapyCognitive functionExtracellular VesiclesGliomaNeural stem cellsRadiation therapy

Identifiers

PMID42103073
PMCPMC13340850

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.