Evidence map›Paper›PMID 42102645›Full record

ReviewCurrent opinion in neurobiology2026

The brain-limb axis: Elucidating CNS mediators of salamander limb regeneration.

Noah Lopez, S Y Celeste Wu, Jessica L Whited

Abstract readReview
In one paragraph

Review in Current opinion in neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Noah LopezDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA, 02138, USA.
S Y Celeste WuDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA, 02138, USA.
Jessica L WhitedDepartment of Stem Cell and Regenerative Biology, Harvard University, 7 Divinity Ave., Cambridge, MA, 02138, USA. Electronic address: jessica_whited@harvard.edu.

Funding

Roles of body-wide injury responses in axolotl limb regenerationR01HD115272 · NICHD · HARVARD UNIVERSITY · PI JESSICA L. WHITED · 2024 to 2026
$2.5M
NICHD NIH HHS R01 HD115272
6 · The paper itself

Abstract

Salamanders have the remarkable ability of regenerating complex tissues such as their limbs, brain, and spinal cord. While the requirement of nerve supply to the damaged tissue has been known for centuries, emerging work has emphasized the possibility of a "brain-limb" axis, in which signals from the brain and spinal cord assist in coordinating local responses to injury. Understanding the molecular underpinnings of how regeneration is coordinated on a body-wide scale may provide further insights into how complex vertebrate regeneration is achieved.

Indexed as

BrainCaudataExtremitiesNerve RegenerationRegenerationAnimalsSpinal Cord

Identifiers

PMID42102645
PMCPMC13321227

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.