Evidence map›Paper›PMID 42102297›Full record

ArticleClinical and translational gastroenterology2026

Reverse Endoscopic Full-Thickness Resection for Gastric Submucosal Tumors With a Predominant Extraluminal Growth Pattern.

Ziyi Li, Zhukai Chen, Weikun Zhang, Lingnan He, Guang Yu, Ajun Gu, Shuxi Liu, Haibin Zhang, Jingjing Lian, Meidong Xu and 1 more

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In one paragraph

Article in Clinical and translational gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Ziyi LiDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Zhukai ChenDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Weikun ZhangDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Lingnan HeDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Guang YuDepartment of Gastroenterology, Taizhou Municipal Hospital, Taizhou, China .
Ajun GuDepartment of Gastroenterology, Taizhou Municipal Hospital, Taizhou, China .
Shuxi LiuDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Haibin ZhangDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Jingjing LianDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Meidong XuDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.
Tao ChenDepartment of Gastroenterology, Endoscopy Center, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China.

Funding

Medical Discipline Construction Project of Pudong Health Committee of Shanghai 2024-PWXZ-07 [M.X.]Medical Discipline Construction Project of Pudong Health Committee of Shanghai 2025PDWSYCBJ-01 [T.C.]Medical Discipline Construction Project of Pudong Health Committee of Shanghai PWZxq2022-6 [M.X.]Shanghai East Hospital 2024-DFZD-005 [M.X.]Shanghai Municipal Health Commission 2024ZDXK0001 [M.X.]
6 · The paper itself

Abstract

introductionLarge gastrointestinal stromal tumors (GISTs) exhibiting a predominantly extraluminal growth pattern are characterized by a rich vascular supply and close proximity to adjacent organs, which pose significant challenges for endoscopic full-thickness resection. The aim of this study was to evaluate the feasibility and therapeutic outcomes of reverse endoscopic full-thickness resection (R-EFTR) for gastric GISTs with a predominantly extraluminal growth pattern.

methodsWe conducted a retrospective analysis of 43 consecutive patients who underwent R-EFTR for gastric GISTs exhibiting a predominant extraluminal growth pattern between March 2019 and December 2024. Data on clinicopathologic characteristics, surgical parameters, and follow-up outcomes were collected and analyzed.

resultsTumor sizes ranged from 2.0 to 5.0 cm, and en bloc resection by R-EFTR was successfully achieved in 41 tumors (95.3%). Notably, tumors larger than 3 cm significantly prolonged operative times ( P < 0.001). Successful closure of gastric wall defects was accomplished using through-the-scope twin clips in 41.9% of cases, while 58.1% were closed using endoloop clips. Closure with endoloop clips was associated with longer procedure time ( P = 0.037). The postoperative follow-up completion rate was 100%, achieved through clinic visits combined with endoscopic ultrasound and computed tomography. During the follow-up period, no patients experienced recurrence or metastasis. DISCUSSION: The findings of our study suggest that R-EFTR is a viable and effective treatment option for GISTs that exhibit a predominantly extraluminal growth pattern and measure between 2 and 5 cm. Tumor size greater than 3 cm was associated with increased procedural complexity, whereas the association with endoloop-clip closure should be interpreted cautiously.

Indexed as

Endoscopic Mucosal ResectionGastrointestinal Stromal TumorsGastroscopyNeoplasm Recurrence, LocalStomach NeoplasmsAdultAgedAged, 80 and overFeasibility StudiesFemaleFollow-Up StudiesGastric MucosaHumansMaleMiddle AgedOperative Timeendoscopic full-thickness resectionextraluminal growth patterngastrointestinal stromal tumors

Identifiers

PMID42102297
PMCPMC13400042

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.