Evidence map›Paper›PMID 42102216›Full record

ArticleScience advances2026

Three cryo-EM structures of complement C3d-bound α

Josefine Lorentzen, Marlene Uglebjerg Fruergaard, Szilvia Lukácsi, Martin Høgholm Jørgensen, Timo Lambertus Gerardus van Veghel, Rasmus Kjeldsen Jensen, Krzysztof Jakub Pietrzak-Lichwa, Zsuzsa Bajtay, Václav Hořejší, Rasmus Kock Flygaard and 3 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Josefine LorentzenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, DK8000, Denmark.ORCID 0000-0003-0219-2168
Marlene Uglebjerg FruergaardDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, DK8000, Denmark.
Szilvia LukácsiMTA-ELTE Immunology Research Group, Eötvös Loránd Research Network (ELKH), Eötvös Loránd University, Budapest, H-1117, Hungary.ORCID 0000-0003-3499-8422
Martin Høgholm JørgensenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, DK8000, Denmark.ORCID 0000-0002-4459-5523
Timo Lambertus Gerardus van VeghelDepartment of Cell Biology and Immunology, Wageningen University and Research, Wageningen, 6708WD, Netherlands.ORCID 0009-0000-6153-0759
Rasmus Kjeldsen JensenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, DK8000, Denmark.ORCID 0000-0001-5472-4862
Krzysztof Jakub Pietrzak-LichwaDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, DK8000, Denmark.ORCID 0009-0008-2058-3027
Zsuzsa BajtayMTA-ELTE Immunology Research Group, Eötvös Loránd Research Network (ELKH), Eötvös Loránd University, Budapest, H-1117, Hungary.
Václav HořejšíInstitute of Molecular Genetics, ASCR, Prague 4, Czech Republic.ORCID 0000-0003-4925-0142
Rasmus Kock FlygaardDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, DK8000, Denmark.ORCID 0000-0002-4918-6438
Daan VorselenDepartment of Cell Biology and Immunology, Wageningen University and Research, Wageningen, 6708WD, Netherlands.ORCID 0000-0002-7800-4023
Simon Arnold MortensenEuropean Molecular Biology Laboratory, Hamburg, 22607, Germany.ORCID 0000-0001-9013-1802
Gregers Rom AndersenDepartment of Molecular Biology and Genetics, Aarhus University, Aarhus, DK8000, Denmark.ORCID 0000-0001-6292-3319

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Integrins are heterodimeric membrane proteins acting as mechanosensing receptors. Nine human α-subunits contain a ligand binding αI domain, but how ligands activate αI integrins are not understood. We present cryo-EM structures of the αI integrin α

Indexed as

Complement C3bCryoelectron MicroscopyMacrophage-1 AntigenHumansLigandsModels, MolecularProtein BindingProtein ConformationComplement C3bLigandsMacrophage-1 Antigen

Identifiers

PMID42102216
PMCPMC13155356

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.