Evidence map›Paper›PMID 42102205›Full record

ReviewScience advances2026

Targeting cGAS-STING signaling to overcome antibiotic-resistant bacterial infections: Challenges and opportunities.

Yu Seong Ham, Minseo Jeong, Chul-Su Yang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yu Seong HamDepartment of Molecular and Life Science, Hanyang University, Ansan-si, Gyeonggi-do 15588, South Korea.ORCID 0009-0009-1263-8443
Minseo JeongDepartment of Molecular and Life Science, Hanyang University, Ansan-si, Gyeonggi-do 15588, South Korea.ORCID 0009-0006-5081-5293
Chul-Su YangDepartment of Molecular and Life Science, Hanyang University, Ansan-si, Gyeonggi-do 15588, South Korea.ORCID 0000-0003-4918-961X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing antibiotic-resistant bacterial infections pose a global public health challenge that demands therapeutic strategies beyond conventional antibiotics. The cyclic guanosine monophosphate-adenosine monophosphate synthase stimulator of interferon genes (cGAS-STING) pathway is crucial to innate immune defense through cytosolic DNA detection and antimicrobial response initiation. Emerging evidence suggests that antibiotic-resistant bacteria can subvert or overactivate this pathway, leading to immune evasion and excessive inflammation. Methicillin-resistant

Indexed as

Anti-Bacterial AgentsBacterial InfectionsDrug Resistance, BacterialMembrane ProteinsNucleotidyltransferasesSignal TransductionAnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseHost-Directed TherapyHost-Pathogen InteractionsHumansImmunity, InnateSTING ProteinAnti-Bacterial AgentscGAS protein, humanCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotidyltransferasesSTING1 protein, humanSTING Protein

Identifiers

PMID42102205
PMCPMC13155295

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.