In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Edismauro Garcia Freitas-FilhoDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.ORCID 0000-0002-1910-1085 Isabella ZaidanDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.ORCID 0000-0001-9434-8814 Daniel Leonardo Alzamora-TerrelDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.ORCID 0000-0002-3793-3440 Carolina BifanoDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.ORCID 0000-0003-3958-2311 Marlon Fortes-RochaDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
Patrícia Alves de CastroDepartamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, Brazil.ORCID 0000-0003-3045-6511 Renan Eugênio Araujo PiraineDepartamento de Bioquímica e Imunologia, FMRP, USP, Ribeirão Preto, SP, Brazil.ORCID 0000-0001-6650-8286 Camila Figueiredo PinzanDepartamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, Brazil.
Caroline Patini de RezendeDepartamento de Bioquímica e Imunologia, FMRP, USP, Ribeirão Preto, SP, Brazil.ORCID 0000-0001-8263-6958 Emilio Boada-RomeroDepartment of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.ORCID 0000-0003-2482-076X Gustavo Henrique GoldmanDepartamento de Ciências Farmacêuticas, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, USP, Ribeirão Preto, Brazil.ORCID 0000-0002-2986-350X Larissa Dias CunhaDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto (FMRP), Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.ORCID 0000-0002-1290-0263 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Noncanonical conjugation of ATG8 proteins, including LC3, to single membranes implicates the autophagy machinery in cell functions unrelated to metabolic stress. One such pathway is LC3-associated phagocytosis (LAP), which aids in phagosome maturation and subsequent signaling upon cargo uptake mediated by certain innate immunity-associated receptors. Here, we show that a specific isoform of RAB5 GTPases, the molecular switches controlling early endosome traffic, is necessary for LAP. We demonstrate that RAB5c regulates phagosome recruitment and function of complexes required for phosphatidylinositol 3-phosphate [PI(3)P] and reactive oxygen species (ROS) generation by macrophages. RAB5c facilitates phagosome translocation of the V-ATPase transmembrane core, which is needed for ATG16L1 binding and consequent LC3 conjugation. RAB5c depletion impaired macrophage elimination of the fungal pathogen
Indexed as
MacrophagesMicrotubule-Associated ProteinsPhagocytosisrab5 GTP-Binding ProteinsAnimalsAspergillus fumigatusAutophagyAutophagy-Related ProteinsEndosomesHumansMicePhagosomesPhosphatidylinositol PhosphatesReactive Oxygen SpeciesVacuolar Proton-Translocating ATPasesAutophagy-Related ProteinsMap1lc3b protein, mouseMicrotubule-Associated Proteinsphosphatidylinositol 3-phosphatePhosphatidylinositol Phosphatesrab5 GTP-Binding ProteinsReactive Oxygen SpeciesVacuolar Proton-Translocating ATPases
Identifiers
PMID42102192
PMCPMC13155314
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