Evidence map›Paper›PMID 42102034›Full record

ArticlePloS one2026

Comparative metabolic profiling, enzyme inhibitory activities, and in-silico analysis of the hexane extract and the hydrodistilled oil of Boswellia serrata.

Heba A S El-Nashar, Esraa A Elhawary, Nilofar Nilofar, Mahmoud A El Hassab, Taghreed A Majrashi, Wagdy Eldehna, Gokhan Zengin, Omayma A Eldahshan

Erratum issuedAbstract readComparative Study
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In one paragraph

Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Heba A S El-NasharDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Esraa A ElhawaryDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.
Nilofar NilofarDepartment of Biology, Science Faculty, Selcuk University, Campus, Konya, Turkey.ORCID https://orcid.org/0000-0002-4254-4140
Mahmoud A El HassabDepartment of Medicinal Chemistry, Faculty of Pharmacy, King Salman International University (KSIU), South Sinai, Egypt.
Taghreed A MajrashiDepartment of Pharmacognosy, College of Pharmacy, King Khalid University, Abha, Asir, Saudi Arabia.
Wagdy EldehnaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, Egypt.
Gokhan ZenginDepartment of Biology, Science Faculty, Selcuk University, Campus, Konya, Turkey.
Omayma A EldahshanDepartment of Pharmacognosy, Faculty of Pharmacy, Ain Shams University, Cairo, Egypt.ORCID https://orcid.org/0000-0002-0972-0560

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frankincense (Boswellia spp.) oleogum resin is a valuable natural source of bioactive phytoconstituents with diverse therapeutic potential. In this study, the hydrodistilled essential oil (EO) and n-hexane extract (HE) of Boswellia serrata gums were analyzed through gas chromatography-mass spectrometry (GC-MS) to determine their phytochemical composition. The GC-MS results in the identification of 62 and 71 components in the EO and HE, respectively. Acetic acid octyl ester (41.09%) and nerolidol (13.64%), were the major components of the EO. Meanwhile, incensole (28.56%), (1S,2E,4S,5R,7E,11E)-cembra-2,7,11-trien-4,5-diol (13.54%), and 24-norursa-3,12-diene (9.25%) in the HE. Regarding the antioxidant effects, the EO exhibited significantly higher antioxidant capacity compared to the HE (DPPH: 9.24 and 6.50 mg TE/g; ABTS: 25.71 and 4.94 mg TE/g), respectively. Moreover, the EO was more potent in the CUPRAC test (61.12 mg TE/g for the essential oil and 50.62 mg TE/g for HE), while the n-hexane extract (72.68 mg TE/g) showed stronger ability than the EO (13.22 mg TE/g) in the FRAP assay. The EO had a higher ability in phosphomolybdenum and metal chelation tests in comparison with the HE extracts. Further, the oil showed more potent inhibitory activity against cholinesterase, α-glucosidase, and tyrosinase than the HE extract. The HE extract was only more active on α-amylase compared to the oil. These findings suggest that olibanum EO possesses potent bioactive compounds that may contribute to the management of oxidative stress and age-related conditions, including Alzheimer's disease, diabetes mellitus, and skin hyperpigmentation.

Indexed as

BoswelliaEnzyme InhibitorsHexanesOils, VolatilePlant ExtractsPlant OilsAntioxidantsGas Chromatography-Mass SpectrometryAntioxidantsEnzyme InhibitorsHexanesn-hexaneOils, VolatilePlant ExtractsPlant Oils

Identifiers

PMID42102034
PMCPMC13155625

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.