Evidence map›Paper›PMID 42102001›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Inflammasome adaptor protein ASC is a mechanistic checkpoint in IL-1β maturation.

Giti Saha, Pratibha Anchi, Richard Wang, Alyssa Biondo, Sadie Meyer, Vinata Kondragunta, Larry L Luchsinger, Ismail Syed, Humayun Sharif, Hao Wu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Giti SahaLaboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.
Pratibha AnchiLaboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.
Richard WangLaboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.
Alyssa BiondoLaboratory of Stem Cell Regenerative Research, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.
Sadie MeyerLaboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.
Vinata KondraguntaLaboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.
Larry L LuchsingerLaboratory of Stem Cell Regenerative Research, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.ORCID 0000-0002-0063-1764
Ismail SyedDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Deaconess Medical Center and Harvard Medical School, Boston, MA 02115.
Humayun SharifDepartment of Biological Sciences, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi 127788, United Arab Emirates.
Hao WuDepartment of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-7281-8579
Venkat Giri MagupalliLaboratory of Molecular and Mechanistic Cell Signaling, Lindsley F. Kimball Research Institute, New York Blood Center, Rye, NY 10580.

Funding

Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI HU, FRANK B · 1992 to 2021
$25.0M
Mitochondrial Regulation of Hematopoietic Stem CellsR01HL135039 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SNOECK, HANS-WILLEM E · 2017 to 2025
$4.5M
Elucidating the functional mechanism of NLRP3 inflammasome activationR01AI177778 · NIAID · BOSTON CHILDREN'S HOSPITAL · PI Hao Wu · 2023 to 2026
$2.8M
Hormetic ER Stress Regulation of Hematopoietic Stem Cell FunctionR01HL155574 · NHLBI · NEW YORK BLOOD CENTER · PI LUCHSINGER, LARRY L · 2021 to 2025
$2.5M
Autophagic regulation of inflammasome-mediated hyperactive state in living macrophagesR21AR079766 · NIAMS · NEW YORK BLOOD CENTER · PI MAGUPALLI, VENKAT GIRI · 2021 to 2023
$677k
A Novel Class of Lipids as Potential Therapeutic Agents to Promote Pancreatic Beta cell Survival and Prevent Type 1 Diabetes.K01DK118041 · NIDDK · BETH ISRAEL DEACONESS MEDICAL CENTER · PI SYED, ISMAIL · 2018 to 2021
$540k
NHLBI NIH HHS R01 HL135039NHLBI NIH HHS R01 HL155574NIAID NIH HHS R01 AI177778NIAMS NIH HHS R21 AR079766NIDDK NIH HHS K01 DK118041NIDDK NIH HHS P30 DK046200
6 · The paper itself

Abstract

Inflammasome activation triggers caspase-1-dependent maturation of pro-interleukin-1β (pro-IL-1β) in an apoptosis-associated speck-like protein containing a CARD (ASC)-dependent manner, yet the mechanism by which pro-IL-1β is physically recruited to the ASC signaling platform has remained undefined. Here, we identify the ASC linker domain (ASC

Indexed as

CARD Signaling Adaptor ProteinsInflammasomesInterleukin-1betaAnimalsCaspase 1HumansMacrophagesMiceMice, Inbred C57BLProtein BindingPyroptosisCARD Signaling Adaptor ProteinsCaspase 1InflammasomesInterleukin-1betaPYCARD protein, humanPycard protein, mouseIL-1βinflammasomespyroptosis

Identifiers

PMID42102001
PMCPMC13167797

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.