ArticleJournal of natural products2026
Genome Mining-Guided Discovery of the Glycosylated Griseorhodin Congener Ruskamycin.
Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- BisCEET: A Visual Browser for Biosynthetic Gene Clusters Aiding in the Identification of Natural Product Variants and Distinct Tailoring Enzymes.Journal of natural products · 2026Article
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Aromatic polyketides from Actinobacteria are a class of natural products with potential for clinical application due to their antibiotic and cytotoxic activities. Among the most complex members are the closely related rubromycins and griseorhodins, which are derived from a pentangular backbone that undergoes extensive oxidative tailoring to afford a characteristic bisbenzannulated spiroketal pharmacophore. Recent insights into the characteristic genetics and enzymology underlying the biosynthesis of these polyketides now enable the bioinformatics-driven search for further congeners. Here, we analyzed 154 available and manually selected rubromycin/griseorhodin biosynthetic gene clusters (BGCs) with the help of the tool BisCEET, which allowed the rapid identification and visualization of "variant-specific tailoring genes" (VSTGs), encoding putative tailoring enzymes required only for individual congeners. This approach revealed a striking BGC variant in the genome of the Actinomycete
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