Evidence map›Paper›PMID 42101733›Full record

ArticleIntensive care medicine experimental2026

Post-treatment with H12-(ADP)-liposomes after LPS challenge ameliorated coagulopathy and critical organ injury in rats.

Kohsuke Hagisawa, Osamu Ishida, Hiroyuki Nakashima, Shinji Takeoka, Yuji Morimoto, Manabu Kinoshita

Abstract read
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In one paragraph

Article in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Kohsuke HagisawaDepartment of Physiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan. hagisawa@ndmc.ac.jp.ORCID http://orcid.org/0000-0002-1600-4570
Osamu IshidaDepartment of Surgery, National Defense Medical College, Tokorozawa, Japan.
Hiroyuki NakashimaDepartment of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Japan.
Shinji TakeokaDepartment of Life Science and Medical Bioscience, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan.
Yuji MorimotoDepartment of Physiology, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, 359-8513, Japan.
Manabu KinoshitaDepartment of Immunology and Microbiology, National Defense Medical College, Tokorozawa, Japan.

Funding

Japan Society for the Promotion of Science 22H03179
6 · The paper itself

Abstract

backgroundLiposomes coated with fibrinogen γ-chain (HHLGGAKQAGDV, H12) peptide and encapsulating adenosine-diphosphate (ADP) [H12-(ADP)-liposomes] can augment platelet aggregation via glycoprotein IIb/IIIa receptors displayed on activated platelets. H12-(ADP)-liposomes release ADP, which is metabolized into adenosine that has tissue-protective effects. This study evaluated the life-saving efficacy of post-treatment with H12-(ADP)-liposomes in rats with LPS-induced coagulopathy and critical organ injuries.

methodsLPS (10 mg/kg) was administered intraperitoneally to rats. The rats were then treated with an intravenous injection of either H12-(ADP)-liposomes or normal saline (vehicle control) 4 h later.

resultsPost-treatment with H12-(ADP)-liposomes significantly shortened the coagulation time compared to the vehicle treatment at 8 h after LPS challenge and reduced expression of CD62P, a marker of platelet activation, on CD61

conclusionsThese findings suggest that post-treatment with H12-(ADP)-liposomes ameliorates LPS-induced coagulopathy and neutrophil activation, thereby improving critical organ injuries and survival in LPS-challenged rats.

Indexed as

And Critical organ injuriesConsumptive coagulopathyPlatelet–leukocyte aggregates

Identifiers

PMID42101733
PMCPMC13156337

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