ReviewArchives of microbiology2026
Overview of functionally characterized two-component regulatory systems in Vibrio parahaemolyticus.
Review in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
Funding
Abstract
Two-component regulatory systems (TCSs) are ubiquitous signal transduction pathways in bacteria, enabling adaptive responses to environmental changes via phosphoryl signaling. In Vibrio parahaemolyticus, a globally significant enteropathogen, TCSs orchestrate survival strategies and pathogenicity. This review synthesizes current knowledge on the composition, signaling mechanisms, and functional roles of key TCSs in V. parahaemolyticus. Systems such as VbrK/VbrR, which senses β-lactams and nitrite to modulate β-lactamase production and suppresses type III secretion system 1 (T3SS1), and ArcB/ArcA, which integrates oxygen-dependent signals into quorum sensing and virulence regulation, highlight the adaptability of this pathogen. Other systems, including BarA/UvrY, PhoB/PhoR, and TtrS/TtrR, further illustrate the regulatory complexity governing metabolism, motility, and host colonization. Despite advances, significant gaps remain in understanding ligand specificity, cross-system interactions, and mechanistic details of transcriptional regulation, particularly for newly identified regulatory targets and auxiliary TCS interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.