Evidence map›Paper›PMID 42101560›Full record

ArticleBiometals : an international journal on the role of metal ions in biology, biochemistry, and medicine2026

Deciphering the role of human peroxiredoxins for combating lead and zinc mediated cellular toxicity using a yeast model.

Rahul Thakur, Reena V Saini, Sasanka Chakrabarti, Adesh K Saini

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Article in Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Rahul ThakurDepartment of Bio-Sciences and Technology, M M Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, Haryana, India.
Reena V SainiDepartment of Bio-Sciences and Technology, M M Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, Haryana, India.
Sasanka ChakrabartiDepartment of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, Haryana, India.
Adesh K SainiDepartment of Bio-Sciences and Technology, M M Engineering College, Maharishi Markandeshwar (Deemed to Be University), Mullana, Ambala, Haryana, India. sainiade@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Elevated levels of heavy metals in cells lead to an imbalance of cellular redox homeostasis which is also seen in zinc and lead ion mediated toxicity. Human peroxiredoxins (hPrxI and hPrxII) are central regulators of redox balance; however, their role in mitigating heavy metal-induced stress remains unclear. Previously, we showed that the Saccharomyces cerevisiae model lacking TSA1 and TSA2 (tsa1tsa2Δ) showed growth defects in the presence of redox stressors that can be rescued by expressing hPrxI and hPrxII. In the present study, we utilized the tsa1tsa2Δ strain to understand the role of human homologs metal ion-induced stress. Growth assays demonstrated that ZnCl

Indexed as

ChloridesLeadPeroxiredoxinsSaccharomyces cerevisiaeZincZinc CompoundsHumansOxidative StressReactive Oxygen SpeciesSaccharomyces cerevisiae ProteinsChloridesLeadlead chloridePeroxiredoxinsReactive Oxygen SpeciesSaccharomyces cerevisiae ProteinsZinczinc chlorideZinc CompoundsHeavy metal toxicityHuman peroxiredoxinsOxidative stressReactive oxygen speciesRedox homeostasis

Identifiers

PMID42101560

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.