Evidence map›Paper›PMID 42101551›Full record

ArticleThe Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology2026

Construction and verification of a diagnostic nomogram for heart failure in hypertrophic cardiomyopathy based on conventional clinical indicators: a case-control study.

Yu Li, Ziqi Duan, Jinlei Li, Bingxin Cheng, Fen Ai, Zhen Chen

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Article in The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Yu Li *Department of Emergency Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Ziqi Duan *Department of Gastrointestinal Surgery, The Sixth Hospital of Wuhan, Affiliated Hospital of Jianghan University, Wuhan, China. 513853272@qq.com.
Jinlei Li *Department of Emergency Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Bingxin ChengDepartment of Emergency Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Fen AiDepartment of Emergency Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. 13006191071@163.com.
Zhen ChenDepartment of Emergency Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. c_z_s_s_@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Heart failure (HF) manifests variably in patients with hypertrophic cardiomyopathy (HCM). This study developed and validated a diagnostic nomogram that uses routine clinical indicators to identify HF in individuals with HCM. Independent diagnostic indicators of HF in patients with HCM included B-type natriuretic peptide (BNP) (OR = 1.003, P < 0.001), diuretics (OR = 3.69, P = 0.014), and myocardial ischemia (OR = 4.99, P = 0.002). The diagnostic model demonstrated robust performance in both the training set and the validation set, yielding AUCs of 0.917 (95% CI: 0.879-0.955) and 0.929 (95% CI: 0.873-0.984), respectively. At an optimal threshold of 0.157, the training set exhibited sensitivity and specificity of 89.1% and 79.9%, respectively, while the validation set showed sensitivity and specificity of 90.9% and 82.9%, respectively. The calibration curve indicated a good fit, and DCA revealed that the model provided a net clinical benefit. In this study, the developed nomogram model accurately identifies HF in patients with HCM, aiding in diagnostic stratification and personalized management.Clinical Trial Registration This study was registered retrospectively at the Chinese Clinical Trial Registry ( http://www.chictr.org.cn/ ), registration number ChiCTR2500106648 (Registration Date: 2025-07-28).

Indexed as

Diagnostic modelHeart failureHypertrophic cardiomyopathyNomogram

Identifiers

PMID42101551
PMCPMC13156373

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.